Mouse Anti-CHRNA2 Recombinant Antibody (CBT2369) (V2LY-0625-LY737)

Name: Mouse Anti-CHRNA2 Recombinant Antibody (CBT2369)
SKU: V2LY-0625-LY737
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-CHRNA2 Recombinant Antibody (CBT2369) (V2LY-0625-LY737) in ELISA

Mouse Anti-CHRNA2 Recombinant Antibody (CBT2369) (V2LY-0625-LY737) in WB

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT2369

Application

Immunogen

Purified recombinant fragment of human CHRNA2 (AA: extra 27-264) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

cholinergic receptor nicotinic alpha 2 subunit

Entrez Gene ID

1135

UniProt ID

Q15822

Function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Biological Process

Chemical synaptic transmission Source: GO_Central
Ion transmembrane transport Source: GO_Central
Ion transport Source: UniProtKB
Nervous system process Source: GO_Central
Regulation of membrane potential Source: GO_Central
Response to nicotine Source: GO_Central
Signal transduction Source: UniProtKB
Synaptic transmission, cholinergic Source: GO_Central

Cellular Location

Postsynaptic cell membrane; Cell membrane

Involvement in disease

Epilepsy, nocturnal frontal lobe, 4 (ENFL4): An autosomal dominant focal epilepsy characterized by nocturnal seizures associated with fear sensation, tongue movements, and nocturnal wandering, closely resembling nightmares and sleep walking.
Seizures, benign familial infantile, 6 (BFIS6): A form of benign familial infantile epilepsy, a neurologic disorder characterized by afebrile seizures occurring in clusters during the first year of life, without neurologic sequelae. BFIS6 inheritance is autosomal dominant.

Topology

Extracellular: 27-264
Helical: 265-289
Helical: 297-315
Helical: 331-352
Cytoplasmic: 353-502
Helical: 503-521

Ma, Y., Liu, S., Jun, H., & Wu, J. (2021). CHRNA2: a new paradigm in beige thermoregulation and metabolism. Trends in cell biology.

Villa, C., Colombo, G., Meneghini, S., Gotti, C., Moretti, M., Ferini-Strambi, L., ... & Combi, R. (2019). CHRNA2 and nocturnal frontal lobe epilepsy: Identification and characterization of a novel loss of function mutation. Frontiers in molecular neuroscience, 12, 17.

Nichol, H., Amilhon, B., Manseau, F., Badrinarayanan, S., & Williams, S. (2018). Electrophysiological and morphological characterization of Chrna2 cells in the subiculum and CA1 of the Hippocampus: an optogenetic investigation. Frontiers in cellular neuroscience, 12, 32.

Hilscher, M. M., Leão, R. N., Edwards, S. J., Leão, K. E., & Kullander, K. (2017). Chrna2-Martinotti cells synchronize layer 5 type A pyramidal cells via rebound excitation. PLoS biology, 15(2), e2001392.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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