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Rat Anti-CHRNA2 Recombinant Antibody (CBWJN-1064) (CBMAB-N0668-WJ)

This product is a Rat antibody that recognizes CHRNA2. The antibody CBWJN-1064 can be used for immunoassay techniques such as: IF, IP, WB.
See all CHRNA2 antibodies

Summary

Host Animal
Rat
Specificity
Rat, Chicken
Clone
CBWJN-1064
Antibody Isotype
IgG2a
Application
IF, IP, WB

Basic Information

Specificity
Rat, Chicken
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
cholinergic receptor nicotinic alpha 2 subunit
Introduction
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. [provided by RefSeq, Nov 2009]
Entrez Gene ID
Rat170945
Chicken395607
UniProt ID
RatP12389
ChickenP09480
Alternative Names
Cholinergic Receptor Nicotinic Alpha 2 Subunit; Cholinergic Receptor, Nicotinic, Alpha Polypeptide 2 (Neuronal); Acetylcholine Receptor, Nicotinic, Alpha 2 (Neuronal); Cholinergic Receptor, Nicotinic, Alpha 2 (Neuronal); Cholinergic Receptor, Nicotinic Alpha 2;
Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Biological Process
Chemical synaptic transmission Source: GO_Central
Ion transmembrane transport Source: GO_Central
Ion transport Source: UniProtKB
Nervous system process Source: GO_Central
Regulation of membrane potential Source: GO_Central
Response to nicotine Source: GO_Central
Signal transduction Source: UniProtKB
Synaptic transmission, cholinergic Source: GO_Central
Cellular Location
Postsynaptic cell membrane; Cell membrane
Involvement in disease
Epilepsy, nocturnal frontal lobe, 4 (ENFL4): An autosomal dominant focal epilepsy characterized by nocturnal seizures associated with fear sensation, tongue movements, and nocturnal wandering, closely resembling nightmares and sleep walking.
Seizures, benign familial infantile, 6 (BFIS6): A form of benign familial infantile epilepsy, a neurologic disorder characterized by afebrile seizures occurring in clusters during the first year of life, without neurologic sequelae. BFIS6 inheritance is autosomal dominant.
Topology
Extracellular: 27-264
Helical: 265-289
Helical: 297-315
Helical: 331-352
Cytoplasmic: 353-502
Helical: 503-521
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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