Mouse Anti-CINP Recombinant Antibody (CBFYC-1874) (CBMAB-C1939-FY)

Name: Mouse Anti-CINP Recombinant Antibody (CBFYC-1874)
SKU: CBMAB-C1939-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBFYC-1874

Application

WB, ELISA, IP

Immunogen

Amino acids 1-212 of CINP of human.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1-212

More Infomation

Target

Full Name

Cyclin Dependent Kinase 2 Interacting Protein

Introduction

The protein encoded by this gene is reported to be a component of the DNA replication complex as well as a genome-maintenance protein. It may interact with proteins important for replication initiation and has been shown to bind chromatin at the G1 phase of the cell cycle and dissociate from chromatin with replication initiation. It may also serve to regulate checkpoint signaling as part of the DNA damage response. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

51550

UniProt ID

Q9BW66

Alternative Names

Cyclin Dependent Kinase 2 Interacting Protein; CDK2-Interacting Protein

Function

Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling.

Biological Process

Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
DNA repair Source: UniProtKB-KW
DNA replication Source: UniProtKB-KW

Cellular Location

Nucleus. Binds to nuclear under G1 conditions, and dissociates from chromatin with the start of DNA replication.

PTM

Phosphorylated by CDC7 but not by CDK2.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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