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Mouse Anti-CISD2 Recombinant Antibody (569) (CBMAB-AP1511LY)


See all CISD2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
569
Antibody Isotype
IgG2b
Application
ELISA, IF, IHC, WB

Basic Information

Immunogen
Fusion protein of Fusion Protein
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CDGSH Iron Sulfur Domain 2
Introduction
The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2. [provided by RefSeq, Mar 2011]
Entrez Gene ID
Human493856
Mouse67006
Rat295457
UniProt ID
HumanQ8N5K1
MouseQ9CQB5
RatD4AAE9
Alternative Names
CDGSH Iron Sulfur Domain 2; Endoplasmic Reticulum Intermembrane Small Protein; Nutrient-Deprivation Autophagy Factor-1; Zinc Finger, CDGSH-Type Domain 2; MitoNEET-Related 1 Protein; Miner1; NAF-1; ZCD2;
Function
Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca2+ stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.
Biological Process
Autophagy of mitochondrion Source: GO_Central
Multicellular organism aging Source: UniProtKB
Regulation of autophagy Source: UniProtKB
Cellular Location
Mitochondrion outer membrane; Endoplasmic reticulum membrane. According to PubMed:20010695, it mainly localizes to the endoplasmic reticulum. However, experiments in mouse showed that it mainly localizes to the mitochondrion outer membrane.
Involvement in disease
Wolfram syndrome 2 (WFS2):
A rare disorder characterized by juvenile-onset insulin-dependent diabetes mellitus with optic atrophy. Other manifestations include diabetes insipidus, sensorineural deafness, dementia, psychiatric illnesses. WFS2 patients additionally show a strong bleeding tendency and gastrointestinal ulceration. Diabetes insipidus may be absent.
Topology
Lumenal: 2-37
Helical: 38-60
Cytoplasmic: 61-135

Kung, W. M., & Lin, M. S. (2021). The NFκB Antagonist CDGSH Iron-Sulfur Domain 2 Is a Promising Target for the Treatment of Neurodegenerative Diseases. International Journal of Molecular Sciences, 22(2), 934.

Kung, W. M., & Lin, M. S. (2021). Beneficial Impacts of Alpha-Eleostearic Acid from Wild Bitter Melon and Curcumin on Promotion of CDGSH Iron-Sulfur Domain 2: Therapeutic Roles in CNS Injuries and Diseases. International Journal of Molecular Sciences, 22(7), 3289.

Shen, Z. Q., Huang, Y. L., Teng, Y. C., Wang, T. W., Kao, C. H., Yeh, C. H., & Tsai, T. F. (2021). CISD2 maintains cellular homeostasis. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 118954.

Kung, W. M., Chang, C. J., Chen, T. Y., & Lin, M. S. (2020). Cryogen spray cooling mitigates inflammation and injury-induced CISD2 decline in rat spinal cord hemisection model. Journal of Integrative Neuroscience, 19(4), 619-628.

Nobili, A., Krashia, P., & D'Amelio, M. (2020). Cisd2: a promising new target in Alzheimer's disease. The Journal of pathology, 251(2), 113-116.

Li, J., Duan, H., Xuan, F., Zhao, E., & Huang, M. (2019). CDGSH iron sulfur domain 2 deficiency inhibits cell proliferation and induces cell differentiation of neuroblastoma. Pathology & Oncology Research, 1-9.

Yeh, C. H., Shen, Z. Q., Hsiung, S. Y., Wu, P. C., Teng, Y. C., Chou, Y. J., ... & Tsai, T. F. (2019). Cisd2 is essential to delaying cardiac aging and to maintaining heart functions. PLoS biology, 17(10), e3000508.

Sun, A. G., Meng, F. G., & Wang, M. G. (2017). CISD2 promotes the proliferation of glioma cells via suppressing beclin‑1‑mediated autophagy and is targeted by microRNA‑449a. Molecular medicine reports, 16(6), 7939-7948.

Yang, Y., Bai, Y. S., & Wang, Q. (2017). CDGSH iron sulfur domain 2 activates proliferation and EMT of pancreatic cancer cells via Wnt/β-catenin pathway and has prognostic value in human pancreatic cancer. Oncology research, 25(4), 605.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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