Mouse Cisd2 ELISA Kit (V2LY-0626-LY2149)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0099 ng/mL
Detection Range
0.02-6 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Mouse
Assay Type
Sandwich
Reactivity
Mouse
Assay Time
1.5 h
Molecule Mass
15.2 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
CDGSH Iron Sulfur Domain 2
Function
Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca2+ stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.
Biological Process
Autophagy of mitochondrion Source: GO_Central
Multicellular organism aging Source: UniProtKB
Regulation of autophagy Source: UniProtKB
Cellular Location
Mitochondrion outer membrane; Endoplasmic reticulum membrane. According to PubMed:20010695, it mainly localizes to the endoplasmic reticulum. However, experiments in mouse showed that it mainly localizes to the mitochondrion outer membrane.
Involvement in disease
Wolfram syndrome 2 (WFS2):
A rare disorder characterized by juvenile-onset insulin-dependent diabetes mellitus with optic atrophy. Other manifestations include diabetes insipidus, sensorineural deafness, dementia, psychiatric illnesses. WFS2 patients additionally show a strong bleeding tendency and gastrointestinal ulceration. Diabetes insipidus may be absent.
Topology
Lumenal: 2-37
Helical: 38-60
Cytoplasmic: 61-135

Kung, W. M., & Lin, M. S. (2021). The NFκB Antagonist CDGSH Iron-Sulfur Domain 2 Is a Promising Target for the Treatment of Neurodegenerative Diseases. International Journal of Molecular Sciences, 22(2), 934.

Kung, W. M., & Lin, M. S. (2021). Beneficial Impacts of Alpha-Eleostearic Acid from Wild Bitter Melon and Curcumin on Promotion of CDGSH Iron-Sulfur Domain 2: Therapeutic Roles in CNS Injuries and Diseases. International Journal of Molecular Sciences, 22(7), 3289.

Shen, Z. Q., Huang, Y. L., Teng, Y. C., Wang, T. W., Kao, C. H., Yeh, C. H., & Tsai, T. F. (2021). CISD2 maintains cellular homeostasis. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 118954.

Kung, W. M., Chang, C. J., Chen, T. Y., & Lin, M. S. (2020). Cryogen spray cooling mitigates inflammation and injury-induced CISD2 decline in rat spinal cord hemisection model. Journal of Integrative Neuroscience, 19(4), 619-628.

Nobili, A., Krashia, P., & D'Amelio, M. (2020). Cisd2: a promising new target in Alzheimer's disease. The Journal of pathology, 251(2), 113-116.

Li, J., Duan, H., Xuan, F., Zhao, E., & Huang, M. (2019). CDGSH iron sulfur domain 2 deficiency inhibits cell proliferation and induces cell differentiation of neuroblastoma. Pathology & Oncology Research, 1-9.

Yeh, C. H., Shen, Z. Q., Hsiung, S. Y., Wu, P. C., Teng, Y. C., Chou, Y. J., ... & Tsai, T. F. (2019). Cisd2 is essential to delaying cardiac aging and to maintaining heart functions. PLoS biology, 17(10), e3000508.

Sun, A. G., Meng, F. G., & Wang, M. G. (2017). CISD2 promotes the proliferation of glioma cells via suppressing beclin‑1‑mediated autophagy and is targeted by microRNA‑449a. Molecular medicine reports, 16(6), 7939-7948.

Yang, Y., Bai, Y. S., & Wang, Q. (2017). CDGSH iron sulfur domain 2 activates proliferation and EMT of pancreatic cancer cells via Wnt/β-catenin pathway and has prognostic value in human pancreatic cancer. Oncology research, 25(4), 605.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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