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Mouse Anti-CITED1 Recombinant Antibody (6G8) (CBMAB-C8332-LY)

This product is antibody recognizes CITED1. The antibody 6G8 immunoassay techniques such as: ELISA, WB.
See all CITED1 antibodies
Published Data

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
6G8
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa94-193 from human CITED1 (NP_004134) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
Introduction
This gene encodes a member of the CREB-binding protein/p300-interacting transactivator with Asp/Glu-rich C-terminal domain (CITED) family of proteins. The encoded protein, also known as melanocyte-specific gene 1, may function as a transcriptional coactivator and may play a role in pigmentation of melanocytes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]
Entrez Gene ID
UniProt ID
Alternative Names
Cbp/P300 Interacting Transactivator With Glu/Asp Rich Carboxy-Terminal Domain 1; Melanocyte-Specific Protein 1; MSG1; Cbp/P300-Interacting Transactivator, With Glu/Asp Rich Carboxy-Terminal Domain, 1; Cbp/P300-Interacting Transactivator 1; Melanocyte-Specific Gene 1;
Function
Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner.
Biological Process
Apoptotic process Source: UniProtKB-KW
Brain development Source: Ensembl
Branching involved in ureteric bud morphogenesis Source: UniProtKB
Embryonic axis specification Source: Ensembl
Labyrinthine layer development Source: Ensembl
Melanin biosynthetic process Source: UniProtKB
Melanocyte differentiation Source: UniProtKB
Mesenchymal to epithelial transition Source: BHF-UCL
Metanephros development Source: BHF-UCL
Negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Source: Ensembl
Negative regulation of neuron apoptotic process Source: UniProtKB
Negative regulation of osteoblast differentiation Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of Wnt signaling pathway Source: BHF-UCL
Nucleocytoplasmic transport Source: UniProtKB
Pigmentation Source: UniProtKB
Placenta development Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of mesenchymal stem cell proliferation Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Positive regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
Regulation of apoptotic process Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: ProtInc
Response to cAMP Source: UniProtKB
Response to cytokine Source: UniProtKB
Response to estrogen Source: UniProtKB
Response to insulin Source: UniProtKB
Response to interferon-gamma Source: UniProtKB
Response to interleukin-1 Source: UniProtKB
Response to interleukin-11 Source: UniProtKB
Response to interleukin-2 Source: UniProtKB
Response to interleukin-4 Source: UniProtKB
Response to interleukin-6 Source: UniProtKB
Response to interleukin-9 Source: UniProtKB
Response to lipopolysaccharide Source: UniProtKB
Response to parathyroid hormone Source: UniProtKB
Response to transforming growth factor beta Source: UniProtKB
SMAD protein signal transduction Source: BHF-UCL
Spongiotrophoblast layer development Source: Ensembl
Transforming growth factor beta receptor signaling pathway Source: BHF-UCL
Vasculogenesis Source: Ensembl
Cellular Location
Nucleus; Cytoplasm. Shuttles between the nucleus and the cytoplasm by a nuclear export signal and (NES) in a CRM1-dependent manner.
PTM
Phosphorylated. Phosphorylation changes in a cell cycle-dependent manner and reduces its transcriptional coactivator activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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