CITED1

This gene encodes a member of the CREB-binding protein/p300-interacting transactivator with Asp/Glu-rich C-terminal domain (CITED) family of proteins. The encoded protein, also known as melanocyte-specific gene 1, may function as a transcriptional coactivator and may play a role in pigmentation of melanocytes. Alternatively spliced transcript variants have been described. [provided by RefSeq]

Full Name

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1

Function

Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner.

Biological Process

Apoptotic process Source: UniProtKB-KW
Brain development Source: Ensembl
Branching involved in ureteric bud morphogenesis Source: UniProtKB
Embryonic axis specification Source: Ensembl
Labyrinthine layer development Source: Ensembl
Melanin biosynthetic process Source: UniProtKB
Melanocyte differentiation Source: UniProtKB
Mesenchymal to epithelial transition Source: BHF-UCL
Metanephros development Source: BHF-UCL
Negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Source: Ensembl
Negative regulation of neuron apoptotic process Source: UniProtKB
Negative regulation of osteoblast differentiation Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of Wnt signaling pathway Source: BHF-UCL
Nucleocytoplasmic transport Source: UniProtKB
Pigmentation Source: UniProtKB
Placenta development Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of mesenchymal stem cell proliferation Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Positive regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
Regulation of apoptotic process Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: ProtInc
Response to cAMP Source: UniProtKB
Response to cytokine Source: UniProtKB
Response to estrogen Source: UniProtKB
Response to insulin Source: UniProtKB
Response to interferon-gamma Source: UniProtKB
Response to interleukin-1 Source: UniProtKB
Response to interleukin-11 Source: UniProtKB
Response to interleukin-2 Source: UniProtKB
Response to interleukin-4 Source: UniProtKB
Response to interleukin-6 Source: UniProtKB
Response to interleukin-9 Source: UniProtKB
Response to lipopolysaccharide Source: UniProtKB
Response to parathyroid hormone Source: UniProtKB
Response to transforming growth factor beta Source: UniProtKB
SMAD protein signal transduction Source: BHF-UCL
Spongiotrophoblast layer development Source: Ensembl
Transforming growth factor beta receptor signaling pathway Source: BHF-UCL
Vasculogenesis Source: Ensembl

Cellular Location

Nucleus; Cytoplasm. Shuttles between the nucleus and the cytoplasm by a nuclear export signal and (NES) in a CRM1-dependent manner.

PTM

Phosphorylated. Phosphorylation changes in a cell cycle-dependent manner and reduces its transcriptional coactivator activity.