Mouse Anti-CITED4 Recombinant Antibody (4F6) (CBMAB-C6945-LY)

Name: Mouse Anti-CITED4 Recombinant Antibody (4F6)
SKU: CBMAB-C6945-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4F6

Application

ELISA, IHC, WB, IF

Immunogen

Partial recombinant protein corresponding to aa131-185 from human CITED4.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
IHC	3 µg/ml
IF(ICC)	10 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4

Introduction

The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors. [provided by RefSeq, Aug 2011]

Entrez Gene ID

163732

UniProt ID

Q96RK1

Alternative Names

Cbp/P300 Interacting Transactivator With Glu/Asp Rich Carboxy-Terminal Domain 4; Transcriptional Co-Activator 4; MSG1-Related Protein 2; MRG-2; Cbp/P300-Interacting Transactivator, With Glu/Asp Rich Carboxy-Terminal Domain, 4; Cbp/P300-Interacting Transactivator 4; MRG2;

Function

Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells.

Biological Process

Positive regulation of transcription by RNA polymerase II Source: Reactome
Response to estrogen Source: UniProtKB

Cellular Location

Nucleus; Cytoplasm

Bahramian, A., Mirzaei, B., Karimzadeh, F., Ramhmaninia, F., Gaeini, A. A., Naderi, N., & Hemmatinafar, M. (2018). The effects of exercise training intensity on the expression of C/EBPβ and CITED4 in rats with myocardial infarction. Asian Journal of Sports Medicine, 9(4).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-CITED4 Recombinant Antibody (HT13-2D6.3) (CAT#: CBMAB-C0722-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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