Sign in or Register   Sign in or Register
  |  

Mouse Anti-CITED4 Recombinant Antibody (4F6) (CBMAB-C6945-LY)

This product is antibody recognizes CITED4. The antibody 4F6 immunoassay techniques such as: ELISA, IHC-F, WB.
See all CITED4 antibodies
Published Data
Fig.1 Strong CITED4 positivity in the cytoplasmic compartment of malignant glands in contrast to entrapped normal elements, where CITED4 is predominantly nuclear; inset, occasional tumors showed strong nuclear expression.
...View More
Fig.2 Western blot analysis of the CITED4-overexpressing permanent and control cell line.
...View More
Fig.3 Western blot validation for a subset of deregulated genes derived from the CITED4-overexpressing/shRNA knockdown cell line microarray analyses.
...View More

Summary

Host Animal
Mouse
Specificity
Human
Clone
4F6
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC-F, WB

Basic Information

Immunogen
Partial recombinant protein corresponding to aa131-185 from human CITED4 (NP_597724) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
Introduction
The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors. [provided by RefSeq, Aug 2011]
Entrez Gene ID
163732
UniProt ID
Q96RK1
Alternative Names
Cbp/P300 Interacting Transactivator With Glu/Asp Rich Carboxy-Terminal Domain 4; Transcriptional Co-Activator 4; MSG1-Related Protein 2; MRG-2; Cbp/P300-Interacting Transactivator, With Glu/Asp Rich Carboxy-Terminal Domain, 4; Cbp/P300-Interacting Transactivator 4; MRG2;
Function
Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells.
Biological Process
Positive regulation of transcription by RNA polymerase II Source: Reactome
Response to estrogen Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CITED4 Recombinant Antibody (4F6)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare