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Mouse Anti-CKB Recombinant Antibody (CBYY-C0667) (CBMAB-C1977-YY)

This product is mouse antibody that recognizes CKB. The antibody CBYY-C0667 can be used for immunoassay techniques such as: WB, FC, ELISA, IF
See all CKB antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C0667
Antibody Isotype
IgG2a, κ
Application
WB, FC, ELISA, IF

Basic Information

Immunogen
Recombinant human CKB (1-381aa) purified from E. coli
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein A purified
Buffer
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Creatine Kinase B
Entrez Gene ID
1152
UniProt ID
P12277
Alternative Names
CD38 Molecule; ADP-Ribosyl Cyclase 1; 2-Phospho-Cyclic-ADP-Ribose Transferase; Cyclic ADP-Ribose Hydrolase 1; 2-Phospho-ADP-Ribosyl Cyclase; NAD(+) Nucleosidase; CD38 Antigen (P45); ADPRC 1; 2-Phospho-ADP-Ribosyl Cyclase/2-Phospho-Cyclic-ADP-Ribose Transferase; Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase;
Function
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
Biological Process
Cellular chloride ion homeostasis Source: Ensembl
Cerebellum development Source: Ensembl
Creatine metabolic process Source: Reactome
Phosphocreatine biosynthetic process Source: GO_Central
Substantia nigra development Source: UniProtKB
Cellular Location
Cytoplasm

Rahbani, J. F., Roesler, A., Hussain, M. F., Samborska, B., Dykstra, C. B., Tsai, L., ... & Kazak, L. (2021). Creatine kinase B controls futile creatine cycling in thermogenic fat. Nature, 590(7846), 480-485.

Krutilina, R. I., Playa, H. C., Brooks, D. L., Schwab, L. P., Parke, D. N., Oluwalana, D., ... & Seagroves, T. N. (2021). HIF-dependent expression of creatine kinase brain isoform (CKB) promotes breast cancer metastasis, and blocking creatine kinase activity with cyclocreatine impairs invasion and improves the efficacy of conventional chemotherapies. bioRxiv.

Sprenger, J., Trifan, A., Patel, N., Vanderbeck, A., Bredfelt, J., Tajkhorshid, E., ... & Linse, S. (2021). Calmodulin complexes with brain and muscle creatine kinase peptides. Current Research in Structural Biology, 3, 121-132.

Jeong, Y. J., Park, S. W., Seo, M. K., Kim, S. J., Lee, W. H., Kim, M., ... & Seog, D. H. (2021). The Heterotrimeric Kinesin-2 Family Member KIF3A Directly Binds to Creatine Kinase B. Journal of Life Science, 31(3), 257-265.

Vallecillo, R. (2021). Determining the Role of Brain-Type Creatine Kinase in the Lungs During Asthma.

Sun, X. B., Lim, G. T., Lee, J., Wan, J. X., Lin, H. Z., Yang, J. M., ... & Park, Y. D. (2018). Effects of osmolytes on the refolding of recombinant Pelodiscus sinensis brain-type creatine kinase. Process Biochemistry, 68, 83-92.

Hwang, J. H. (2017). Effects of obesity on protein kinase C, brain creatine kinase, transcription, and autophagy in cochlea. Metabolic brain disease, 32(3), 735-742.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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