Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Rabbit Anti-CLDN11 Recombinant Antibody (CBCNC-186) (V2LY-1206-LY5)


See all CLDN11 antibodies
Online Inquiry

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBCNC-186
Antibody Isotype
IgG
Application
FC, WB

Basic Information

Immunogen
A synthesized peptide derived from human Oligodendrocyte Specific Protein.
Host Species
Rabbit
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
FC1:100
WB1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Claudin 11
Entrez Gene ID
Human5010
Mouse18417
Rat84588
UniProt ID
HumanO75508
MouseQ60771
RatQ99P82
Function
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Biological Process
Axon ensheathment Source: Ensembl
Bicellular tight junction assembly Source: GO_Central
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
Cell adhesion Source: GO_Central
Spermatogenesis Source: Ensembl
Tight junction assembly Source: ARUK-UCL
Cellular Location
Cell membrane; Tight junction
Topology
Cytoplasmic: 1
Helical: 2-22
Extracellular: 23-82
Helical: 83-103
Cytoplasmic: 104-122
Helical: 123-143
Extracellular: 144-157
Helical: 158-178
Cytoplasmic: 179-207
More Infomation

Pörtner, C., Rode, K., Hollenbach, J., Thiemeyer, H., Beineke, A., Günzel-Apel, A. R., & Brehm, R. (2020). Expression of claudin-11 in canine prepubertal testes, and in canine adult testes showing normal spermatogenesis, impaired spermatogenesis, or testicular neoplasia. Theriogenology, 148, 122-131.

Kato, T., Mizuno, K., Nishio, H., Moritoki, Y., Kamisawa, H., Kurokawa, S., ... & Yasui, T. (2020). Disorganization of claudin‐11 and dysfunction of the blood‐testis barrier during puberty in a cryptorchid rat model. Andrology, 8(5), 1398-1408.

Li, C. F., Chen, J. Y., Ho, Y. H., Hsu, W. H., Wu, L. C., Lan, H. Y., ... & Yang, M. H. (2019). Snail-induced claudin-11 prompts collective migration for tumour progression. Nature cell biology, 21(2), 251-262.

Lindsey, R. C., Xing, W., Pourteymoor, S., Godwin, C., Gow, A., & Mohan, S. (2019). Novel role for Claudin‐11 in the regulation of osteoblasts via modulation of ADAM10‐mediated notch signaling. Journal of Bone and Mineral Research, 34(10), 1910-1922.

Horné, F., Dietze, R., Berkes, E., Oehmke, F., Tinneberg, H. R., Meinhold-Heerlein, I., & Konrad, L. (2019). Impaired localization of claudin-11 in endometriotic epithelial cells compared to endometrial cells. Reproductive Sciences, 26(9), 1181-1192.

Baek, J. M., Cheon, Y. H., Kwak, S. C., Jun, H. Y., Yoon, K. H., Lee, M. S., & Kim, J. Y. (2018). Claudin 11 regulates bone homeostasis via bidirectional EphB4-EphrinB2 signaling. Experimental & molecular medicine, 50(4), 1-18.

Shen, Z., Cao, B., Lin, L., Zhou, C., Ye, D., Qiu, S., ... & Cui, X. (2017). The clinical signification of claudin-11 promoter hypermethylation for laryngeal squamous cell carcinoma. Medical science monitor: international medical journal of experimental and clinical research, 23, 3635.

Li, J., Zhou, C., Ni, S., Wang, S., Ni, C., Yang, P., & Ye, M. (2017). Methylated claudin-11 associated with metastasis and poor survival of colorectal cancer. Oncotarget, 8(56), 96249.

Yang, P., Zhang, M., Liu, X., & Pu, H. (2017). MicroRNA-421 promotes the proliferation and metastasis of gastric cancer cells by targeting claudin-11. Experimental and therapeutic medicine, 14(3), 2625-2632.

Nissinen, L., Siljamäki, E., Riihilä, P., Piipponen, M., Farshchian, M., Kivisaari, A., ... & Kähäri, V. M. (2017). Expression of claudin‐11 by tumor cells in cutaneous squamous cell carcinoma is dependent on the activity of p38δ. Experimental dermatology, 26(9), 771-777.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-CLDN11 Recombinant Antibody (CBCNC-186)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry