Human Recombinant CLDN11 protein, Fc Tag (V2LY-0526-LY3196)

Name: Human Recombinant CLDN11 protein, Fc Tag
SKU: V2LY-0526-LY3196
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

Fc Tag

Protein Construction

This product is Human Recombinant CLDN11 protein, Fc Tag consist of Amino Acid: 23-82 and predicts a molecular mass of 33.2 kDa.

Molecule Mass

33.2 kDa

Sequence

Amino Acid: 23-82

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Claudin 11

Function

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Biological Process

Axon ensheathment Source: Ensembl
Bicellular tight junction assembly Source: GO_Central
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
Cell adhesion Source: GO_Central
Spermatogenesis Source: Ensembl
Tight junction assembly Source: ARUK-UCL

Cellular Location

Cell membrane; Tight junction

Topology

Cytoplasmic: 1
Helical: 2-22
Extracellular: 23-82
Helical: 83-103
Cytoplasmic: 104-122
Helical: 123-143
Extracellular: 144-157
Helical: 158-178
Cytoplasmic: 179-207

Pörtner, C., Rode, K., Hollenbach, J., Thiemeyer, H., Beineke, A., Günzel-Apel, A. R., & Brehm, R. (2020). Expression of claudin-11 in canine prepubertal testes, and in canine adult testes showing normal spermatogenesis, impaired spermatogenesis, or testicular neoplasia. Theriogenology, 148, 122-131.

Kato, T., Mizuno, K., Nishio, H., Moritoki, Y., Kamisawa, H., Kurokawa, S., ... & Yasui, T. (2020). Disorganization of claudin‐11 and dysfunction of the blood‐testis barrier during puberty in a cryptorchid rat model. Andrology, 8(5), 1398-1408.

Li, C. F., Chen, J. Y., Ho, Y. H., Hsu, W. H., Wu, L. C., Lan, H. Y., ... & Yang, M. H. (2019). Snail-induced claudin-11 prompts collective migration for tumour progression. Nature cell biology, 21(2), 251-262.

Lindsey, R. C., Xing, W., Pourteymoor, S., Godwin, C., Gow, A., & Mohan, S. (2019). Novel role for Claudin‐11 in the regulation of osteoblasts via modulation of ADAM10‐mediated notch signaling. Journal of Bone and Mineral Research, 34(10), 1910-1922.

Horné, F., Dietze, R., Berkes, E., Oehmke, F., Tinneberg, H. R., Meinhold-Heerlein, I., & Konrad, L. (2019). Impaired localization of claudin-11 in endometriotic epithelial cells compared to endometrial cells. Reproductive Sciences, 26(9), 1181-1192.

Baek, J. M., Cheon, Y. H., Kwak, S. C., Jun, H. Y., Yoon, K. H., Lee, M. S., & Kim, J. Y. (2018). Claudin 11 regulates bone homeostasis via bidirectional EphB4-EphrinB2 signaling. Experimental & molecular medicine, 50(4), 1-18.

Shen, Z., Cao, B., Lin, L., Zhou, C., Ye, D., Qiu, S., ... & Cui, X. (2017). The clinical signification of claudin-11 promoter hypermethylation for laryngeal squamous cell carcinoma. Medical science monitor: international medical journal of experimental and clinical research, 23, 3635.

Li, J., Zhou, C., Ni, S., Wang, S., Ni, C., Yang, P., & Ye, M. (2017). Methylated claudin-11 associated with metastasis and poor survival of colorectal cancer. Oncotarget, 8(56), 96249.

Yang, P., Zhang, M., Liu, X., & Pu, H. (2017). MicroRNA-421 promotes the proliferation and metastasis of gastric cancer cells by targeting claudin-11. Experimental and therapeutic medicine, 14(3), 2625-2632.

Nissinen, L., Siljamäki, E., Riihilä, P., Piipponen, M., Farshchian, M., Kivisaari, A., ... & Kähäri, V. M. (2017). Expression of claudin‐11 by tumor cells in cutaneous squamous cell carcinoma is dependent on the activity of p38δ. Experimental dermatology, 26(9), 771-777.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human CLDN11 ELISA Kit (CAT#: V2LY-0626-LY2792)

Related Products

Human CLDN11 ELISA Kit (CAT#: V2LY-0626-LY2792)

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Rabbit Anti-CLDN11 Recombinant Antibody (CBCNC-186) (CAT#: V2LY-1206-LY5)

Mouse Anti-CLDN11 Recombinant Antibody (CBXC-1173) (CAT#: V2LY-1206-LY4)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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