Rat Anti-CLEC12A Recombinant Antibody (CBXC-0847) (V2LY-1206-LY87)

Name: Rat Anti-CLEC12A Recombinant Antibody (CBXC-0847)
SKU: V2LY-1206-LY87
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBXC-0847

Application

Immunogen

Recombinant mouse MICL/CLEC12A with an N-terminal 9-His tag Thr67-Arg267.

Host Species

Rat

Specificity

Mouse

Antibody Isotype

IgG2a

Clonality

Monoclonal Antibody

Application Notes

Application	Note
FC	0.25 µg/10^6 cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Antibody

Buffer

PBS, Trehalose

Preservative

None

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

C-Type Lectin Domain Family 12 Member A

Entrez Gene ID

66864

UniProt ID

Q8VCP9

Function

Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.

Biological Process

Neutrophil degranulation Source: Reactome

Cellular Location

Cell membrane. Ligand binding leads to internalization.

Topology

Cytoplasmic: 1-43
Helical: 44-64
Extracellular: 65-265

PTM

Highly N-glycosylated. Glycosylation varies between cell types.

Vitry, J., Paré, G., Murru, A., Charest-Morin, X., Maaroufi, H., McLeish, K. R., ... & Fernandes, M. J. (2021). Regulation of the Expression, Oligomerisation and Signaling of the Inhibitory Receptor CLEC12A by Cysteine Residues in the Stalk Region. International journal of molecular sciences, 22(19), 10207.

Álvarez, B., Nieto-Pelegrín, E., Martínez De La Riva, P., Toki, D., Poderoso, T., Revilla, C., ... & Domínguez, J. (2020). Characterization of the porcine CLEC12A and analysis of its expression on blood dendritic cell subsets. Frontiers in immunology, 11, 863.

Bill, M., Aggerholm, A., Kjeldsen, E., Roug, A. S., Hokland, P., & Nederby, L. (2019). Revisiting CLEC 12A as leukaemic stem cell marker in AML: highlighting the necessity of precision diagnostics in patients eligible for targeted therapy. British journal of haematology, 184(5), 769-781.

Bill, M., B. van Kooten Niekerk, P., S. Woll, P., Laine Herborg, L., Stidsholt Roug, A., Hokland, P., & Nederby, L. (2018). Mapping the CLEC 12A expression on myeloid progenitors in normal bone marrow; implications for understanding CLEC 12A‐related cancer stem cell biology. Journal of cellular and molecular medicine, 22(4), 2311-2318.

Li, K. (2018). The C-type lectin receptor Clec12A positively regulates type I interferon response (Doctoral dissertation, Technische Universität München).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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