CLEC12A

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13. [provided by RefSeq, May 2011]
Full Name
C-Type Lectin Domain Family 12 Member A
Function
Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.
Biological Process
Neutrophil degranulation Source: Reactome
Cellular Location
Cell membrane. Ligand binding leads to internalization.
Topology
Cytoplasmic: 1-43
Helical: 44-64
Extracellular: 65-265
PTM
Highly N-glycosylated. Glycosylation varies between cell types.
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Anti-CLEC12A antibodies

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Mouse Recombinant CLEC12A protein, His Tag (V2LY-0526-LY8131)

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Target: CLEC12A
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 65-267
Tag: His Tag
Datasheet SDS

Human Recombinant CLEC12A protein, PE Conjugated, His Tag (V2LY-0526-LY3240)

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Target: CLEC12A
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 75-275
Tag: His Tag
Datasheet SDS

Human Recombinant CLEC12A protein, hFc Tag (V2LY-0526-LY3239)

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Target: CLEC12A
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 75-275
Tag: hFc Tag
Datasheet SDS

Human Recombinant CLEC12A protein, ECD, His Tag (V2LY-0526-LY3238)

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Target: CLEC12A
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 75-275
Tag: His Tag
Datasheet SDS

Human Recombinant CLEC12A protein, Biotin Conjugated, AVI & Fc Tag (V2LY-0526-LY3237)

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Target: CLEC12A
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 75-275
Tag: AVI & Fc Tag
Datasheet SDS

Human Recombinant CLEC12A protein, APC Conjugated, His Tag (V2LY-0526-LY3236)

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Target: CLEC12A
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 75-275
Tag: His Tag
Datasheet SDS

Human Recombinant CLEC12A protein, AF647 Conjugated, His Tag (V2LY-0526-LY3235)

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Target: CLEC12A
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 75-275
Tag: His Tag
Datasheet SDS

Human Recombinant CLEC12A protein, AF488 Conjugated, His Tag (V2LY-0526-LY3234)

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Target: CLEC12A
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 75-275
Tag: His Tag
Datasheet SDS

Mouse Anti-CLEC12A Recombinant Antibody (CBT3934) (V2LY-0625-LY1163)

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Target: CLEC12A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3934
Application*: F
Datasheet SDS

Mouse Anti-CLEC12A Recombinant Antibody (CBT4159) (V2LY-0625-LY1034)

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Target: CLEC12A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT4159
Application*: WB, IC, F
Datasheet SDS

Rat Anti-CLEC12A Recombinant Antibody (CBXC-0847) (V2LY-1206-LY87)

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Target: CLEC12A
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXC-0847
Application*: F
Datasheet SDS

Mouse Anti-CLEC12A Recombinant Antibody (CBYY-C3229) (V2LY-1206-LY86)

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Target: CLEC12A
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-C3229
Application*: F
Datasheet SDS

Rat Anti-CLEC12A Recombinant Antibody (CBYY-C0360) (V2LY-1206-LY85)

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Target: CLEC12A
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYY-C0360
Application*: F
Datasheet SDS

Rabbit Anti-CLEC12A Recombinant Antibody (CBYY-C0307) (V2LY-1206-LY84)

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Target: CLEC12A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-C0307
Application*: E, F
Datasheet SDS

Rabbit Anti-CLEC12A Recombinant Antibody (C7958) (V2LY-1206-LY83)

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Target: CLEC12A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: C7958
Application*: F, IH, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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