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Rabbit Anti-CLEC4M Recombinant Antibody (16E8) (V2LY-1206-LY167)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
16E8
Antibody Isotype
IgG
Application
IF, WB

Basic Information

Immunogen
Recombinant protein of human CD299/DC-SIGNR.
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:1,000-1:5,000
IF(ICC)1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 0.05% BSA, 50% glycerol
Preservative
0.05% sodium azide
Concentration
1.5 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
C-Type Lectin Domain Family 4 Member M
Entrez Gene ID
10332
UniProt ID
Q9H2X3
Function
Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.

(Microbial infection) Acts as an attachment receptor for Ebolavirus.

(Microbial infection) Acts as an attachment receptor for Hepatitis C virus.

(Microbial infection) Acts as an attachment receptor for HIV-1.

(Microbial infection) Acts as an attachment receptor for Human coronavirus 229E.

(Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5.

(Microbial infection) Acts as an attachment receptor for Influenzavirus.

(Microbial infection) Acts as an attachment receptor for SARS-CoV.

(Microbial infection) Acts as an attachment receptor for West-nile virus.

(Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus.

(Microbial infection) Acts as an attachment receptor for Marburg virus glycoprotein.

(Microbial infection) Recognition of M.bovis by dendritic cells may occur partially via this molecule.
Biological Process
Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation Source: UniProtKB
Cell-cell recognition Source: UniProtKB
Endocytosis Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
Intracellular signal transduction Source: UniProtKB
Intracellular transport of virus Source: UniProtKB
Leukocyte cell-cell adhesion Source: UniProtKB
Modulation by virus of host process Source: UniProtKB
Peptide antigen transport Source: UniProtKB
Viral entry into host cell Source: FlyBase
Viral genome replication Source: UniProtKB
Virion attachment to host cell Source: UniProtKB
Cellular Location
Isoform 1&2&3: Cell membrane
Isoform 5&6&7&10: Secreted
Topology
Cytoplasmic: 1-49
Helical: 50-70
Extracellular: 71-399
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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