Human Recombinant CD299 protein, hFc Tag (V2LY-0526-LY3513)

Name: Human Recombinant CD299 protein, hFc Tag
SKU: V2LY-0526-LY3513
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant CD299 protein, hFc Tag consist of Amino Acid: 78-399 and predicts a molecular mass of 65 kDa.

Molecule Mass

65 kDa

Sequence

Amino Acid: 78-399

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

C-Type Lectin Domain Family 4 Member M

Function

Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.

(Microbial infection) Acts as an attachment receptor for Ebolavirus.

(Microbial infection) Acts as an attachment receptor for Hepatitis C virus.

(Microbial infection) Acts as an attachment receptor for HIV-1.

(Microbial infection) Acts as an attachment receptor for Human coronavirus 229E.

(Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5.

(Microbial infection) Acts as an attachment receptor for Influenzavirus.

(Microbial infection) Acts as an attachment receptor for SARS-CoV.

(Microbial infection) Acts as an attachment receptor for West-nile virus.

(Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus.

(Microbial infection) Acts as an attachment receptor for Marburg virus glycoprotein.

(Microbial infection) Recognition of M.bovis by dendritic cells may occur partially via this molecule.

Biological Process

Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation Source: UniProtKB
Cell-cell recognition Source: UniProtKB
Endocytosis Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
Intracellular signal transduction Source: UniProtKB
Intracellular transport of virus Source: UniProtKB
Leukocyte cell-cell adhesion Source: UniProtKB
Modulation by virus of host process Source: UniProtKB
Peptide antigen transport Source: UniProtKB
Viral entry into host cell Source: FlyBase
Viral genome replication Source: UniProtKB
Virion attachment to host cell Source: UniProtKB

Cellular Location

Isoform 1&2&3: Cell membrane
Isoform 5&6&7&10: Secreted

Topology

Cytoplasmic: 1-49
Helical: 50-70
Extracellular: 71-399

Swystun, L. L., Notley, C., Georgescu, I., Lai, J. D., Nesbitt, K., James, P. D., & Lillicrap, D. (2019). The endothelial lectin clearance receptor CLEC 4M binds and internalizes factor VIII in a VWF‐dependent and independent manner. Journal of Thrombosis and Haemostasis, 17(4), 681-694.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CD299 proteinECD (CAT#: V2LY-0526-LY3512)

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Human Recombinant CD299 proteinECD (CAT#: V2LY-0526-LY3512)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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