Mouse Anti-CLIP2 Recombinant Antibody (CBYY-C2981) (V2LY-1206-LY243)

Name: Mouse Anti-CLIP2 Recombinant Antibody (CBYY-C2981)
SKU: V2LY-1206-LY243
Rating: 5 (1 reviews)

See all CLIP2 antibodies

Online Inquiry

Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat

Clone

CBYY-C2981

Antibody Isotype

IgG1, κ

Application

WB, IP, IF

Basic Information

Immunogen

Amino acids 801-917 of CLIP-115 of rat.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.1% gelatin

Preservative

<0.1% sodium azide

Concentration

0.2 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

CAP-Gly Domain Containing Linker Protein 2

Entrez Gene ID

Human	7461
Mouse	269713
Rat	29264

UniProt ID

Human	Q9UDT6
Mouse	Q9Z0H8
Rat	O55156

Function

Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity).

Biological Process

Cytoplasmic microtubule organization Source: GO_Central

Cellular Location

Cytoskeleton; Cytoplasm. Localizes preferentially to the ends of tyrosinated microtubules.

Involvement in disease

CLIP2 is located in the Williams-Beuren syndrome (WBS) critical region (PubMed:9799601). WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of CLIP2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. However, it has been demonstrated that haploinsufficiency of this gene alone is not sufficient to cause any of the cognitive or facial features of WBS (PubMed:22608712).

More Infomation

References

Ding, R., Li, X., Zhu, X. M., Song, Q. X., Fan, Q. H., Zhang, Z. H., & Gong, Q. X. (2020). Inflammatory myofibroblastic tumor arising from soft tissues of extremities harboring a novel CLIP2‐ALK fusion. Pathology International, 70(10), 798-803.

Kruse, R., Krantz, J., Barker, N., Coletta, R., Rafikov, R., Luo, M., ... & Langlais, P. R. (2017). The CLASP2 protein interaction network in adipocytes links CLIP2 to AGAP3, CLASP2 to G2L1, MARK2, and SOGA1, and identifies SOGA1 as a microtubule-associated protein. Mol Cell Proteomics, 16, 1718-1735.

Q & As

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Review & reward

Have you used Mouse Anti-CLIP2 Recombinant Antibody (CBYY-C2981)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email: