Mouse Clip2 ELISA Kit (V2LY-0626-LY2112)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0091 ng/mL
Detection Range
0.02-4.5 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Mouse
Assay Type
Sandwich
Reactivity
Mouse
Assay Time
1.5 h
Molecule Mass
115.9 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
CAP-Gly Domain Containing Linker Protein 2
Function
Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity).
Biological Process
Cytoplasmic microtubule organization Source: GO_Central
Cellular Location
Cytoskeleton; Cytoplasm. Localizes preferentially to the ends of tyrosinated microtubules.
Involvement in disease
CLIP2 is located in the Williams-Beuren syndrome (WBS) critical region (PubMed:9799601). WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of CLIP2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. However, it has been demonstrated that haploinsufficiency of this gene alone is not sufficient to cause any of the cognitive or facial features of WBS (PubMed:22608712).

Ding, R., Li, X., Zhu, X. M., Song, Q. X., Fan, Q. H., Zhang, Z. H., & Gong, Q. X. (2020). Inflammatory myofibroblastic tumor arising from soft tissues of extremities harboring a novel CLIP2‐ALK fusion. Pathology International, 70(10), 798-803.

Kruse, R., Krantz, J., Barker, N., Coletta, R., Rafikov, R., Luo, M., ... & Langlais, P. R. (2017). The CLASP2 protein interaction network in adipocytes links CLIP2 to AGAP3, CLASP2 to G2L1, MARK2, and SOGA1, and identifies SOGA1 as a microtubule-associated protein. Mol Cell Proteomics, 16, 1718-1735.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-CLIP2 Recombinant Antibody (CBYY-C2981) (CAT#: V2LY-1206-LY243)

Isotype control

For research use only. Not intended for any clinical use.

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