Mouse Anti-CLK3 Recombinant Antibody (1F10) (V2LY-1206-LY246)

Name: Mouse Anti-CLK3 Recombinant Antibody (1F10)
SKU: V2LY-1206-LY246
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1F10

Application

ELISA, IF, IHC-P, WB

Immunogen

CLK3 (36 a.a. ~ 136 a.a) partial recombinant protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
IF(ICC)	10 µg/ml
IHC-P	3 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

CDC-like kinase 3

Entrez Gene ID

1198

UniProt ID

P49761

Function

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.

Biological Process

Protein autophosphorylation Source: Ensembl
Protein phosphorylation Source: UniProtKB
Regulation of RNA splicing Source: UniProtKB

Cellular Location

Isoform 1: Nucleus; Cytoplasm; Acrosome
Isoform 2: Nucleus speckle. Co-localizes with serine- and arginine-rich (SR) proteins in the nuclear speckles.

PTM

Autophosphorylates on all three types of residues.

Campbell, T., Hawsawi, O., & Odero-Marah, V. (2022). Abstract PR-17: The role of HMGA2 and CLK3 in prostate cancer health disparities.

Li, H., Cui, X., Hu, Q., Chen, X., & Zhou, P. (2019). CLK3 is a direct target of mir-144 and contributes to aggressive progression in hepatocellular carcinoma. OncoTargets and therapy, 12, 9201.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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