CLK3

This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. [provided by RefSeq]
Full Name
CDC-like kinase 3
Function
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
Biological Process
Protein autophosphorylation Source: Ensembl
Protein phosphorylation Source: UniProtKB
Regulation of RNA splicing Source: UniProtKB
Cellular Location
Isoform 1: Nucleus; Cytoplasm; Acrosome
Isoform 2: Nucleus speckle. Co-localizes with serine- and arginine-rich (SR) proteins in the nuclear speckles.
PTM
Autophosphorylates on all three types of residues.
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Anti-CLK3 antibodies

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Human Recombinant CLK3 protein, GST Tag (V2LY-0526-LY3231)

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Target: CLK3
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-490
Tag: GST Tag
Datasheet SDS

Human Recombinant CLK3, Active protein, GST Tag (V2LY-0526-LY3230)

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Target: CLK3
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: Full Length
Tag: GST Tag
Datasheet SDS

Mouse Anti-CLK3 Recombinant Antibody (CBXC-1537) (V2LY-1206-LY251)

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Target: CLK3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXC-1537
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CLK3 Recombinant Antibody (CBFYC-1948) (V2LY-1206-LY250)

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Target: CLK3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-1948
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-CLK3 Recombinant Antibody (CBFYC-1947) (V2LY-1206-LY249)

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Target: CLK3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-1947
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-CLK3 Recombinant Antibody (1H2) (V2LY-1206-LY248)

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Target: CLK3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Rat
Clone: 1H2
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-CLK3 Recombinant Antibody (3C11) (V2LY-1206-LY247)

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Target: CLK3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3C11
Application*: E, WB
Datasheet SDS

Mouse Anti-CLK3 Recombinant Antibody (1F10) (V2LY-1206-LY246)

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Target: CLK3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1F10
Application*: E, IF, P, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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