Mouse Anti-COL4A3 Recombinant Antibody (CBCNC-272) (V2LY-1206-LY677)
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Basic Information
| Application | Note |
| IHC | 5-20 μg/ml |
| WB | 0.5-2 μg/ml |
| IF(ICC) | 5-20 μg/ml |
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Tumstatin, a cleavage fragment corresponding to the collagen alpha 3(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity; these two anti-tumor properties may be regulated via RGD-independent ITGB3-mediated mechanisms.
Blood circulation Source: ProtInc
Cell adhesion Source: UniProtKB-KW
Cell surface receptor signaling pathway Source: UniProtKB
Collagen-activated tyrosine kinase receptor signaling pathway Source: Ensembl
Collagen fibril organization Source: Reactome
Endothelial cell apoptotic process Source: UniProtKB
Extracellular matrix organization Source: GO_Central
Glomerular basement membrane development Source: UniProtKB
Negative regulation of angiogenesis Source: UniProtKB
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of vascular endothelial cell proliferation Source: UniProtKB
Response to glucose Source: Ensembl
Sensory perception of sound Source: ProtInc
Alport syndrome 2, autosomal recessive (ATS2):
A syndrome characterized by progressive glomerulonephritis, glomerular basement membrane defects, renal failure, sensorineural deafness and specific eye abnormalities (lenticonous and macular flecks). The disorder shows considerable heterogeneity in that families differ in the age of end-stage renal disease and the occurrence of deafness.
Hematuria, benign familial (BFH):
An autosomal dominant condition characterized by non-progressive isolated microscopic hematuria that does not result in renal failure. It is characterized pathologically by thinning of the glomerular basement membrane.
Alport syndrome 3, autosomal dominant (ATS3):
A syndrome characterized by progressive glomerulonephritis, glomerular basement membrane defects, renal failure, sensorineural deafness and specific eye abnormalities (lenticonous and macular flecks). The disorder shows considerable heterogeneity in that families differ in the age of end-stage renal disease and the occurrence of deafness.
Isoform 2 contains an additional N-linked glycosylation site.
Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.
The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues.
Phosphorylated. Thought to be phosphorylated by CERT, but CERT does not have kinase activity.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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