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Mouse Anti-COL6A2 Recombinant Antibody (EG777) (V2LY-1206-LY698)


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Published Data
V2LY-1206-LY698-1
Mouse Anti-COL6A2 Recombinant Antibody (EG777) (V2LY-1206-LY698) in IF
DRGs treated with control-antibody (an antibody against GAPHD) exhibited radially aligned axon bundles. The antibodies to different COL6 α chains gave rise to disorganized axons in varying degrees. ...View More
Fang, Z., & Zou, J. L. (2021). Recombinant COL6 α2 as a self-organization factor that triggers orderly nerve regeneration without guidance cues. Frontiers in Cellular Neuroscience, 15, 816781.
Distributed under Open Access license CC BY 4.0, without modification.
V2LY-1206-LY698-2
Mouse Anti-COL6A2 Recombinant Antibody (EG777) (V2LY-1206-LY698) in IF
After 8 weeks of repair, the longitudinal sections with immunofluorescence staining showed regenerated nerve tissues from the COL6 α2 and vehicle groups. ...View More
Fang, Z., & Zou, J. L. (2021). Recombinant COL6 α2 as a self-organization factor that triggers orderly nerve regeneration without guidance cues. Frontiers in Cellular Neuroscience, 15, 816781.
Distributed under Open Access license CC BY 4.0, without modification.
V2LY-1206-LY698-3
Mouse Anti-COL6A2 Recombinant Antibody (EG777) (V2LY-1206-LY698) in Immunoblot
Validation of temporal profiles by immunoblot of HFFFs infected with VACV (MOI = 5). Viral proteins D8 and C6 were representative of late and early gene expression, respectively. ...View More
Soday, L., Lu, Y., Albarnaz, J. D., Davies, C. T., Antrobus, R., Smith, G. L., & Weekes, M. P. (2019). Quantitative temporal proteomic analysis of vaccinia virus infection reveals regulation of histone deacetylases by an interferon antagonist. Cell reports, 27(6), 1920-1933.
Distributed under Open Access license CC BY 4.0, without modification.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
EG777
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 241-540 mapping within an internal region of COL6A2 of human.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1% gelatin
Preservative
<0.1% sodium azide
Concentration
0.2 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Collagen Type VI Alpha 2 Chain
Entrez Gene ID
Human1292
Mouse12834
UniProt ID
HumanP12110
MouseQ02788
Function
Collagen VI acts as a cell-binding protein.
Biological Process
Cell adhesion Source: UniProtKB-KW
Collagen fibril organization Source: Reactome
Extracellular matrix organization Source: Reactome
Response to glucose Source: Ensembl
Cellular Location
Extracellular matrix; Membrane. Recruited on membranes by CSPG4.
Involvement in disease
Bethlem myopathy 1 (BTHLM1):
A benign proximal myopathy characterized by early childhood onset and joint contractures most frequently affecting the elbows and ankles.
Ullrich congenital muscular dystrophy 1 (UCMD1):
A congenital myopathy characterized by muscle weakness and multiple joint contractures, generally noted at birth or early infancy. The clinical course is more severe than in Bethlem myopathy.
Myosclerosis autosomal recessive (MYOSAR):
A condition characterized by chronic inflammation of skeletal muscle with hyperplasia of the interstitial connective tissue. The clinical picture includes slender muscles with firm 'woody' consistency and restriction of movement of many joints because of muscle contractures.
PTM
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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