Rabbit Anti-CPLX1 Recombinant Antibody (C2751) (V2LY-1206-LY954)

Name: Rabbit Anti-CPLX1 Recombinant Antibody (C2751)
SKU: V2LY-1206-LY954
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

C2751

Application

WB, IP, IF

Immunogen

Recombinant protein specific to human Complexin-1 protein.

Host Species

Rabbit

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:1,000
IF(ICC)	1:50
IHC-P	1:50

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

100 µg/ml BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Complexin 1

Entrez Gene ID

Human	10815
Mouse	12889
Rat	64832

UniProt ID

Human	O14810
Mouse	P63040
Rat	P63041

Function

Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:21785414).

Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse (PubMed:21785414).

Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior.

Biological Process

Chemical synaptic transmission Source: ProtInc
Exocytic insertion of neurotransmitter receptor to postsynaptic membrane Source: Ensembl
Exocytosis Source: ProtInc
Insulin secretion Source: Ensembl
Neurotransmitter secretion Source: Reactome
Neurotransmitter transport Source: Reactome
Regulation of exocytosis Source: ParkinsonsUK-UCL
Regulation of neurotransmitter secretion Source: GO_Central
Regulation of synaptic vesicle fusion to presynaptic active zone membrane Source: Ensembl
Synaptic vesicle exocytosis Source: GO_Central

Cellular Location

Cytosol; Perikaryon; Presynapse. Enriched at synaptic-releasing sites in mature neurons.

Involvement in disease

Developmental and epileptic encephalopathy 63 (DEE63):
A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE63 is an autosomal recessive disease with onset in infancy.

Lux, U. T., Ehrenberg, J., Joachimsthaler, A., Atorf, J., Pircher, B., Reim, K., ... & Brandstätter, J. H. (2021). Cell Types and Synapses Expressing the SNARE Complex Regulating Proteins Complexin 1 and Complexin 2 in Mammalian Retina. International Journal of Molecular Sciences, 22(15), 8131.

Xu, Y., Zhao, X. M., Liu, J., Wang, Y. Y., Xiong, L. L., He, X. Y., & Wang, T. H. (2020). Complexin I knockout rats exhibit a complex neurobehavioral phenotype including profound ataxia and marked deficits in lifespan. Pflügers Archiv-European Journal of Physiology, 472(1), 117-133.

Lahut, S., Gispert, S., Ömür, Ö., Depboylu, C., Seidel, K., Domínguez-Bautista, J. A., ... & Auburger, G. (2017). Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease. Disease models & mechanisms, 10(5), 619-631.

Redler, S., Strom, T. M., Wieland, T., Cremer, K., Engels, H., Distelmaier, F., ... & Wieczorek, D. (2017). Variants in CPLX1 in two families with autosomal-recessive severe infantile myoclonic epilepsy and ID. European Journal of Human Genetics, 25(7), 889-893.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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