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Mouse Anti-CREB3L4 Recombinant Antibody (CBXC-1765) (V2LY-1206-LY1115)

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Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
CBXC-1765
Application
WB, ELISA, IF
Immunogen
CREB3L4 (aa1-110) partial recombinant protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
IF(ICC)10 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
CAMP Responsive Element Binding Protein 3 Like 4
Entrez Gene ID
148327
UniProt ID
Q8TEY5
Function
Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity).
Biological Process
Endoplasmic reticulum unfolded protein response Source: InterPro
Positive regulation of transcription by RNA polymerase II Source: ParkinsonsUK-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Spermatogenesis Source: Ensembl
Cellular Location
Endoplasmic reticulum membrane; Golgi apparatus membrane. May also be located in Golgi apparatus.
Processed cyclic AMP-responsive element-binding protein 3-like protein 4: Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
Topology
Cytoplasmic: 1-295
Helical: 296-316
Lumenal: 317-395
PTM
N-glycosylated in the C-terminal region.
Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region (By similarity).

Pu, Q., Lu, L., Dong, K., Geng, W. W., Lv, Y. R., & Gao, H. D. (2020). The novel transcription factor CREB3L4 contributes to the progression of human breast carcinoma. Journal of Mammary Gland Biology and Neoplasia, 25(1), 37-50.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

CREB3L4 Matched Antibody Pair (299) (CAT#: APMAB-299LY)

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Mouse Anti-CREB3L4 Recombinant Antibody (CBFYC-2197) (CAT#: V2LY-1206-LY1114)

Mouse Anti-CREB3L4 Recombinant Antibody (CBLC-LY-016) (CAT#: V2LY-1206-LY1113)

Mouse Anti-CREB3L4 Recombinant Antibody (0241) (CAT#: CBMAB-0241-YC)

Mouse Anti-CREB3L4 Recombinant Antibody (CBXC-2359) (CAT#: CBMAB-C5555-CQ)

CREB3L4 Matched Antibody Pair (299) (CAT#: APMAB-299LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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