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CREB3L4

CREB3L4 (CAMP Responsive Element Binding Protein 3 Like 4) is a Protein Coding gene. Diseases associated with CREB3L4 include Prostate Cancer. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is CREB3L3.
Full Name
CAMP Responsive Element Binding Protein 3 Like 4
Function
Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity).
Biological Process
Endoplasmic reticulum unfolded protein response Source: InterPro
Positive regulation of transcription by RNA polymerase II Source: ParkinsonsUK-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Spermatogenesis Source: Ensembl
Cellular Location
Endoplasmic reticulum membrane; Golgi apparatus membrane. May also be located in Golgi apparatus.
Processed cyclic AMP-responsive element-binding protein 3-like protein 4: Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
Topology
Cytoplasmic: 1-295
Helical: 296-316
Lumenal: 317-395
PTM
N-glycosylated in the C-terminal region.
Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region (By similarity).

Anti-CREB3L4 antibodies

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Mouse Anti-CREB3L4 Recombinant Antibody (CBWJC-3071) (CBMAB-C4238WJ)

Datasheet SDS
Target: CREB3L4
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBWJC-3071
Application*: WB, IP, IF, E

Mouse Anti-CREB3L4 Recombinant Antibody (CBXC-2359) (CBMAB-C5555-CQ)

Datasheet SDS
Target: CREB3L4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBXC-2359
Application*: WB

Mouse Anti-CREB3L4 Recombinant Antibody (CBXC-1765) (CBMAB-C5554-CQ)

Datasheet SDS
Target: CREB3L4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXC-1765
Application*: WB, IP, IF, E

Mouse Anti-CREB3L4 (AA 1-300 ) Recombinant Antibody (CBFYC-2197) (CBMAB-C2267-FY)

Datasheet SDS
Target: CREB3L4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBFYC-2197
Application*: WB

Mouse Anti-CREB3L4 Antibody (1A3) (CBMAB-0241-YC)

Datasheet SDS
Target: CREB3L4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1A3
Application*: IP, WB, M

Mouse Anti-CREB3L4 Recombinant Antibody (CBLC-LY-016) (CBMAB-C9415-LY)

Datasheet SDS
Target: CREB3L4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLC-LY-016
Application*: E, IF, WB

Mouse Anti-CREB3L4 Recombinant Antibody (1165CT16.1.1) (CBMAB-C2465-LY)

Datasheet SDS
Target: CREB3L4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: 1165CT16.1.1
Application*: WB

Mouse Anti-CREB3L4 Recombinant Antibody (CBLNA-170) (CBMAB-1434-CN)

Datasheet SDS
Target: CREB3L4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLNA-170
Application*: WB, E, IF

Rabbit Anti-CREB3L4 Recombinant Antibody (EPR7382) (CBMAB-1433-CN)

Datasheet SDS
Target: CREB3L4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EPR7382
Application*: WB, IC

Mouse Anti-CREB3L4 Recombinant Antibody (CBLC184-LY) (CBMAB-C11169-LY)

Datasheet SDS
Target: CREB3L4
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBLC184-LY
Application*: WB, IP, IF, E

Mouse Anti-CREB3L4 Recombinant Antibody (CBCNC-079) (CBMAB-C0973-CN)

Datasheet SDS
Target: CREB3L4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBCNC-079
Application*: E, IF, WB

CREB3L4 Matched Antibody Pair (299) (APMAB-299LY)

Datasheet SDS
Target: CREB3L4
Specificity: Human
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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