CREB3L4

CREB3L4 (CAMP Responsive Element Binding Protein 3 Like 4) is a Protein Coding gene. Diseases associated with CREB3L4 include Prostate Cancer. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is CREB3L3.
Full Name
CAMP Responsive Element Binding Protein 3 Like 4
Function
Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity).
Biological Process
Endoplasmic reticulum unfolded protein response Source: InterPro
Positive regulation of transcription by RNA polymerase II Source: ParkinsonsUK-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Spermatogenesis Source: Ensembl
Cellular Location
Endoplasmic reticulum membrane; Golgi apparatus membrane. May also be located in Golgi apparatus.
Processed cyclic AMP-responsive element-binding protein 3-like protein 4: Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
Topology
Cytoplasmic: 1-295
Helical: 296-316
Lumenal: 317-395
PTM
N-glycosylated in the C-terminal region.
Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region (By similarity).
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Anti-CREB3L4 antibodies

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Mouse Anti-CREB3L4 Recombinant Antibody (CBXC-2359) (CBMAB-C5555-CQ)

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Target: CREB3L4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBXC-2359
Application*: WB
Datasheet SDS

Mouse Anti-CREB3L4 Recombinant Antibody (0241) (CBMAB-0241-YC)

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Target: CREB3L4
Host: Mouse
Antibody Isotype: IgG2c, κ
Specificity: Human
Clone: 1A3
Application*: F, IF, P
Datasheet SDS

Mouse Anti-CREB3L4 Recombinant Antibody (CBXC-1765) (V2LY-1206-LY1115)

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Target: CREB3L4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXC-1765
Application*: WB, E, IF
Datasheet SDS

Mouse Anti-CREB3L4 Recombinant Antibody (CBFYC-2197) (V2LY-1206-LY1114)

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Target: CREB3L4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-2197
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CREB3L4 Recombinant Antibody (CBLC-LY-016) (V2LY-1206-LY1113)

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Target: CREB3L4
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBLC-LY-016
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CREB3L4 Recombinant Antibody (CBLNA-170) (V2LY-1206-LY1112)

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Target: CREB3L4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBLNA-170
Application*: WB, IP, IF, E
Datasheet SDS

CREB3L4 Matched Antibody Pair (299) (APMAB-299LY)

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Target: CREB3L4
Specificity: Human
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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