Mouse Anti-CRP Recombinant Antibody (CBFYC-2233) (CBMAB-C2303-FY)

Name: Mouse Anti-CRP Recombinant Antibody (CBFYC-2233)
SKU: CBMAB-C2303-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYC-2233

Application

Immunogen

Human plasma-derived CRP.

Host Species

Mouse

Specificity

Human, Mouse, Pig

Antibody Isotype

IgG2a

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	0.5 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, Trehalose

Preservative

None

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

C-Reactive Protein

Introduction

CRP (C-Reactive Protein) is a Protein Coding gene. Diseases associated with CRP include Acute Pancreatitis and Appendicitis. Among its related pathways are Creation of C4 and C2 activators and Overview of nanoparticle effects. Gene Ontology (GO) annotations related to this gene include calcium ion binding and cholesterol binding. An important paralog of this gene is APCS.

Entrez Gene ID

Human	1401
Mouse	12944

UniProt ID

Human	P02741
Mouse	P14847

Alternative Names

C-Reactive Protein; C-Reactive Protein, Pentraxin-Related; Pentraxin 1; PTX1

Function

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

Biological Process

Acute-phase response Source: BHF-UCL
Complement activation, classical pathway Source: GO_Central
Defense response to Gram-positive bacterium Source: BHF-UCL
Inflammatory response Source: ProtInc
Innate immune response Source: GO_Central
Negative regulation by host of viral process Source: GO_Central
Negative regulation of lipid storage Source: BHF-UCL
Negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
Negative regulation of mononuclear cell proliferation Source: CACAO
Opsonization Source: BHF-UCL
Positive regulation of gene expression Source: AgBase
Positive regulation of superoxide anion generation Source: AgBase
Regulation of interleukin-8 production Source: UniProtKB
Vasoconstriction Source: GO_Central

Cellular Location

Secreted

Luo, X., Zhou, W., Yan, X., Guo, T., Wang, B., Xia, H., ... & Yang, W. (2020). Prognostic value of C-reactive protein in patients with coronavirus 2019. Clinical Infectious Diseases, 71(16), 2174-2179.

Wang, G., Wu, C., Zhang, Q., Wu, F., Yu, B., Lv, J., ... & Zhong, Y. (2020, May). C-reactive protein level may predict the risk of COVID-19 aggravation. In Open forum infectious diseases (Vol. 7, No. 5, p. ofaa153). US: Oxford University Press.

Pathak, A., & Agrawal, A. (2019). Evolution of C-reactive protein. Frontiers in immunology, 10, 943.

Sproston, N. R., & Ashworth, J. J. (2018). Role of C-reactive protein at sites of inflammation and infection. Frontiers in immunology, 9, 754.

Ticinesi, A., Lauretani, F., Nouvenne, A., Porro, E., Fanelli, G., Maggio, M., & Meschi, T. (2017). C-reactive protein (CRP) measurement in geriatric patients hospitalized for acute infection. European Journal of Internal Medicine, 37, 7-12.

Nehring, S. M., & Patel, B. C. (2017). C reactive protein (CRP).

Moutachakkir, M., Baraou, A., Boukhira, A., & Chellak, S. (2017, April). Immunoanalytical characteristics of C-reactive protein and high sensitivity C-reactive protein. In Annales de biologie clinique (Vol. 75, No. 2, pp. 225-229).

Köhler-Forsberg, O., Buttenschøn, H. N., Tansey, K. E., Maier, W., Hauser, J., Dernovsek, M. Z., ... & Mors, O. (2017). Association between C-reactive protein (CRP) with depression symptom severity and specific depressive symptoms in major depression. Brain, behavior, and immunity, 62, 344-350.

Stirling, A. D., Moran, N. R., Kelly, M. E., Ridgway, P. F., & Conlon, K. C. (2017). The predictive value of C-reactive protein (CRP) in acute pancreatitis–is interval change in CRP an additional indicator of severity?. Hpb, 19(10), 874-880.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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