CRP
CRP (C-Reactive Protein) is a Protein Coding gene. Diseases associated with CRP include Acute Pancreatitis and Appendicitis. Among its related pathways are Creation of C4 and C2 activators and Overview of nanoparticle effects. Gene Ontology (GO) annotations related to this gene include calcium ion binding and cholesterol binding. An important paralog of this gene is APCS.
Full Name
C-Reactive Protein
Function
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
Biological Process
Acute-phase response Source: BHF-UCL
Complement activation, classical pathway Source: GO_Central
Defense response to Gram-positive bacterium Source: BHF-UCL
Inflammatory response Source: ProtInc
Innate immune response Source: GO_Central
Negative regulation by host of viral process Source: GO_Central
Negative regulation of lipid storage Source: BHF-UCL
Negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
Negative regulation of mononuclear cell proliferation Source: CACAO
Opsonization Source: BHF-UCL
Positive regulation of gene expression Source: AgBase
Positive regulation of superoxide anion generation Source: AgBase
Regulation of interleukin-8 production Source: UniProtKB
Vasoconstriction Source: GO_Central
Complement activation, classical pathway Source: GO_Central
Defense response to Gram-positive bacterium Source: BHF-UCL
Inflammatory response Source: ProtInc
Innate immune response Source: GO_Central
Negative regulation by host of viral process Source: GO_Central
Negative regulation of lipid storage Source: BHF-UCL
Negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
Negative regulation of mononuclear cell proliferation Source: CACAO
Opsonization Source: BHF-UCL
Positive regulation of gene expression Source: AgBase
Positive regulation of superoxide anion generation Source: AgBase
Regulation of interleukin-8 production Source: UniProtKB
Vasoconstriction Source: GO_Central
Cellular Location
Secreted
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Anti-CRP antibodies
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Target: CRP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Human
Clone: C4504
Application*: WB, E, IP
Target: CRP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 10F7
Application*: E, IH
Target: CRP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2318
Application*: IH, F
Target: CRP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-1027
Application*: E
Target: CRP
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-C2872
Application*: E, WB
Target: CRP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C2871
Application*: WB
Target: CRP
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYY-C2868
Application*: E, WB
Target: CRP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: CBYY-C2867
Application*: E
Target: CRP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-2232
Application*: E
Target: CRP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat
Clone: CBFYC-2230
Application*: WB
Target: CRP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2228
Application*: E, WB
Target: CRP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-2224
Application*: E
Target: CRP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2223
Application*: E
Target: CRP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2221
Application*: E
Target: CRP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Mouse, Rat
Clone: CBFYC-2220
Application*: WB, E, IP
Target: CRP
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: C7026
Application*: WB
Target: CRP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: C4246
Application*: E
Target: CRP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 069
Application*: E
Target: CRP
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXC-1407
Application*: E
Target: CRP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Pig
Clone: CBFYC-2233
Application*: WB
Target: CRP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-2231
Application*: E
Target: CRP
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-2229
Application*: E, IH
Target: CRP
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-0374
Application*: WB, IP, IF
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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