Rat Anti-CST6 Recombinant Antibody (CBYY-C2252) (V2LY-0125-LY143)

Name: Rat Anti-CST6 Recombinant Antibody (CBYY-C2252)
SKU: V2LY-0125-LY143
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBYY-C2252

Application

Neutralization, WB, IP

Immunogen

Recombinant mouse Cystatin E/M, Glu29-Val149.

Host Species

Rat

Specificity

Mouse

Antibody Isotype

IgG2b

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1 μg/mL
IP	25 μg/mL

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS & Trehalose

Preservative

None

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

cystatin E/M

Entrez Gene ID

73720

UniProt ID

Q9D1B1

Function

High affinity inhibitor for cathepsin L, cathepsin L2 (cathepsin V), and legumain (PubMed:30425301).

Involved in the regulation of epidermal cornification, and hair follicle morphogenesis and maintenance (PubMed:30425301).

Biological Process

Anatomical structure morphogenesis Source: ProtInc
Epidermis development Source: Ensembl

Cellular Location

Secreted

Involvement in disease

Ectodermal dysplasia 15, hypohidrotic/hair type (ECTD15):
A form of ectodermal dysplasia, a disorder due to abnormal development of two or more ectodermal structures. ECTD15 is an autosomal recessive form characterized by hypotrichosis and absence of sweating except with extreme exercise. Skin is dry from birth and eczematous lesions may develop in adulthood. Other features include blepharitis and photophobia.

PTM

Substrate for transglutaminases. Acts as an acyl acceptor but not as an acyl donor.

Xu, D., Ding, S., Cao, M., Yu, X., Wang, H., Qiu, D., ... & Li, K. (2021). A Pan-Cancer Analysis of Cystatin E/M Reveals Its Dual Functional Effects and Positive Regulation of Epithelial Cell in Human Tumors. Frontiers in genetics, 1676.

Lalmanach, G., Kasabova-Arjomand, M., Lecaille, F., & Saidi, A. (2021). Cystatin m/e (Cystatin 6): a janus-faced cysteine protease inhibitor with both tumor-suppressing and tumor-promoting functions. Cancers, 13(8), 1877.

Li, X., Liang, Y., Lian, C., Peng, F., Xiao, Y., He, Y., ... & Hu, G. (2021). CST6 protein and peptides inhibit breast cancer bone metastasis by suppressing CTSB activity and osteoclastogenesis. Theranostics, 11(20), 9821.

Eckl, K. M., Gruber, R., Brennan, L., Marriott, A., Plank, R., Moosbrugger-Martinz, V., ... & Schmuth, M. (2021). Cystatin M/E variant causes autosomal dominant keratosis follicularis spinulosa decalvans by dysregulating cathepsins L and V. Frontiers in Genetics, 12, 1227.

Gai, D., Stewart, J. P., Shen, X., Chen, J. R., Li, C., Peng, B., ... & Zhan, F. (2020). CST6 Is a Small Autocrine Molecule That Targets Myeloma Growth and Bone Destruction. Blood, 136, 21.

Li, Q., Zheng, Z. C., Ni, C. J., Jin, W. X., Jin, Y. X., Chen, Y., ... & Cai, Y. F. (2018). Correlation of cystatin E/M with clinicopathological features and prognosis in triple-negative breast cancer. Annals of Clinical & Laboratory Science, 48(1), 40-44.

Wallin, H., Apelqvist, J., Andersson, F., Ekström, U., & Abrahamson, M. (2017). Low-level internalization of cystatin E/M affects legumain activity and migration of melanoma cells. Journal of Biological Chemistry, 292(35), 14413-14424.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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