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CST6

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype. [provided by RefSeq]
Full Name
cystatin E/M
Function
High affinity inhibitor for cathepsin L, cathepsin L2 (cathepsin V), and legumain (PubMed:30425301).

Involved in the regulation of epidermal cornification, and hair follicle morphogenesis and maintenance (PubMed:30425301).
Biological Process
Anatomical structure morphogenesis Source: ProtInc
Epidermis development Source: Ensembl
Cellular Location
Secreted
Involvement in disease
Ectodermal dysplasia 15, hypohidrotic/hair type (ECTD15):
A form of ectodermal dysplasia, a disorder due to abnormal development of two or more ectodermal structures. ECTD15 is an autosomal recessive form characterized by hypotrichosis and absence of sweating except with extreme exercise. Skin is dry from birth and eczematous lesions may develop in adulthood. Other features include blepharitis and photophobia.
PTM
Substrate for transglutaminases. Acts as an acyl acceptor but not as an acyl donor.

Anti-CST6 antibodies

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Rabbit Anti-CST6 Recombinant Antibody (CBYY-C2201) (CBMAB-C3639-YY)

Datasheet SDS
Target: CST6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-C2201
Application*: E

Mouse Anti-CST6 Recombinant Antibody (CBYY-C2225) (CBMAB-C3663-YY)

Datasheet SDS
Target: CST6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C2225
Application*: E, E(Det)

Mouse Anti-CST6 Recombinant Antibody (CBYY-C2230) (CBMAB-C3668-YY)

Datasheet SDS
Target: CST6
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYY-C2230
Application*: F, IH, N

Rat Anti-CST6 Recombinant Antibody (CBYY-C2252) (CBMAB-C3690-YY)

Datasheet SDS
Target: CST6
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-C2252
Application*: N, WB

Rat Anti-CST6 Recombinant Antibody (216820) (CBMAB-C0635-LY)

Datasheet SDS
Target: CST6
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 216820
Application*: WB, IP, N

Rabbit Anti-CST6 Recombinant Antibody (022) (CBMAB-C1680-LY)

Datasheet SDS
Target: CST6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 022
Application*: EC

Rabbit Anti-CST6 Recombinant Antibody (034) (CBMAB-C1720-LY)

Datasheet SDS
Target: CST6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 034
Application*: E

Mouse Anti-CST6 Recombinant Antibody (17) (CBMAB-C3407-LY)

Datasheet SDS
Target: CST6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 17
Application*: P

Mouse Anti-CST6 Recombinant Antibody (2H8) (CBMAB-C5304-LY)

Datasheet SDS
Target: CST6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2H8
Application*: E, WB

Rabbit Anti-CST6 Recombinant Antibody (34) (CBMAB-C5538-LY)

Datasheet SDS
Target: CST6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 34
Application*: E

Mouse Anti-CST6 Recombinant Antibody (4E7C10B7) (CBMAB-C6889-LY)

Datasheet SDS
Target: CST6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4E7C10B7
Application*: E, ED

Mouse Anti-CST6 Recombinant Antibody (4H54) (CBMAB-C7064-LY)

Datasheet SDS
Target: CST6
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 4H54
Application*: F, IH, N

Rat Anti-CST6 Recombinant Antibody (6F49) (CBMAB-C8273-LY)

Datasheet SDS
Target: CST6
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 6F49
Application*: N, WB

Mouse Anti-CST6 Recombinant Antibody (CBFYC-2346) (CBMAB-C2418-FY)

Datasheet SDS
Target: CST6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2346
Application*: E

Mouse Anti-CST6 Recombinant Antibody (CBFYC-2347) (CBMAB-C2419-FY)

Datasheet SDS
Target: CST6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2347
Application*: P

Mouse Anti-CST6 Recombinant Antibody (CBCNC-428) (CBMAB-C3010-CN)

Datasheet SDS
Target: CST6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBCNC-428
Application*: E

Mouse Anti-CST6 Recombinant Antibody (MM0231-4H54) (CBMAB-C11260-LY)

Datasheet SDS
Target: CST6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MM0231-4H54
Application*: F

Rat Anti-CST6 Recombinant Antibody (RM0217-6F49) (CBMAB-C11262-LY)

Datasheet SDS
Target: CST6
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: RM0217-6F49
Application*: WB, B/N

Rabbit Anti-CST6 Recombinant Antibody (CBCNC-429) (CBMAB-C3011-CN)

Datasheet SDS
Target: CST6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBCNC-429
Application*: E

Mouse Anti-CST6 Recombinant Antibody (CBXC-2570) (CBMAB-C0937-CQ)

Datasheet SDS
Target: CST6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2570
Application*: F, IH, P, N, MC

Rat Anti-CST6 Recombinant Antibody (CBXC-1500) (CBMAB-C3493-CQ)

Datasheet SDS
Target: CST6
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBXC-1500
Application*: N, WB

Mouse Anti-CST6 Recombinant Antibody (CBXC-1012) (CBMAB-C5396-CQ)

Datasheet SDS
Target: CST6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-1012
Application*: WB, IH, IP, N
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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