CST6

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype. [provided by RefSeq]
Full Name
cystatin E/M
Function
High affinity inhibitor for cathepsin L, cathepsin L2 (cathepsin V), and legumain (PubMed:30425301).

Involved in the regulation of epidermal cornification, and hair follicle morphogenesis and maintenance (PubMed:30425301).
Biological Process
Anatomical structure morphogenesis Source: ProtInc
Epidermis development Source: Ensembl
Cellular Location
Secreted
Involvement in disease
Ectodermal dysplasia 15, hypohidrotic/hair type (ECTD15):
A form of ectodermal dysplasia, a disorder due to abnormal development of two or more ectodermal structures. ECTD15 is an autosomal recessive form characterized by hypotrichosis and absence of sweating except with extreme exercise. Skin is dry from birth and eczematous lesions may develop in adulthood. Other features include blepharitis and photophobia.
PTM
Substrate for transglutaminases. Acts as an acyl acceptor but not as an acyl donor.
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Anti-CST6 antibodies

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Mouse Anti-CST6 Recombinant Antibody (CBYY-C2230) (CBMAB-C3668-YY)

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Target: CST6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-C2230
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-CST6 Recombinant Antibody (17) (CBMAB-C3407-LY)

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Target: CST6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 17
Application*: E
Datasheet SDS

Rabbit Anti-CST6 Recombinant Antibody (034) (CBMAB-C1720-LY)

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Target: CST6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 034
Application*: E
Datasheet SDS

Mouse Anti-CST6 Recombinant Antibody (CBCNC-428) (V2LY-0125-LY147)

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Target: CST6
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBCNC-428
Application*: N, WB, P
Functional Assay
Datasheet SDS

Mouse Anti-CST6 Recombinant Antibody (CBXC-1012) (V2LY-0125-LY146)

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Target: CST6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-1012
Application*: WB, IH, IP, N
Functional Assay
Datasheet SDS

Rat Anti-CST6 Recombinant Antibody (CBXC-2570) (V2LY-0125-LY144)

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Target: CST6
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBXC-2570
Application*: WB, IP
Datasheet SDS

Rat Anti-CST6 Recombinant Antibody (CBYY-C2252) (V2LY-0125-LY143)

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Target: CST6
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYY-C2252
Application*: N, WB, IP
Functional Assay
Datasheet SDS

Mouse Anti-CST6 Recombinant Antibody (CBYY-C2225) (V2LY-0125-LY141)

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Target: CST6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2225
Application*: E
Datasheet SDS

Mouse Anti-CST6 Recombinant Antibody (CBFYC-2347) (V2LY-0125-LY140)

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Target: CST6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2347
Application*: P
Datasheet SDS

Mouse Anti-CST6 Recombinant Antibody (CBFYC-2346) (V2LY-0125-LY139)

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Target: CST6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-2346
Application*: E, WB
Datasheet SDS

Rabbit Anti-CST6 Recombinant Antibody (34) (V2LY-0125-LY138)

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Target: CST6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 34
Application*: E
Datasheet SDS

Rabbit Anti-CST6 Recombinant Antibody (022) (V2LY-0125-LY135)

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Target: CST6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 022
Application*: E
Datasheet SDS

Rat Anti-CST6 Recombinant Antibody (C0635) (V2LY-0125-LY134)

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Target: CST6
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: C0635
Application*: N, WB
Functional Assay
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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