Mouse Anti-CSTF2 Recombinant Antibody (CBYY-C2223) (V2LY-0125-LY192)

Name: Mouse Anti-CSTF2 Recombinant Antibody (CBYY-C2223)
SKU: V2LY-0125-LY192
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBYY-C2223

Antibody Isotype

IgG1, κ

Application

ELISA, IF, WB

Basic Information

Immunogen

Full length recombinant CSTF2.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
IF(ICC)	3 μg/mL

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Cleavage Stimulation Factor Subunit 2

Entrez Gene ID

1478

UniProt ID

P33240

Function

One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity).

Biological Process

mRNA 3'-end processing Source: Reactome
mRNA polyadenylation Source: InterPro
mRNA splicing, via spliceosome Source: Reactome
Pre-mRNA cleavage required for polyadenylation Source: GO_Central
Termination of RNA polymerase II transcription Source: Reactome
tRNA splicing, via endonucleolytic cleavage and ligation Source: Reactome

Cellular Location

Nucleus. Localized with DDX1 in cleavage bodies.

More Infomation

References

Masoumzadeh, E., Grozdanov, P. N., Jetly, A., MacDonald, C. C., & Latham, M. P. (2022). Electrostatic interactions between CSTF2 and pre-mRNA drive cleavage and polyadenylation. Biophysical Journal.

Mamoor, S. (2021). Differential expression of cleavage stimulation factor subunit 2 in cancers of the breast.

Grozdanov, P. N., Masoumzadeh, E., Kalscheuer, V. M., Bienvenu, T., Billuart, P., Delrue, M. A., ... & MacDonald, C. C. (2020). A missense mutation in the CSTF2 gene that impairs the function of the RNA recognition motif and causes defects in 3′ end processing is associated with intellectual disability in humans. Nucleic acids research, 48(17), 9804-9821.

Chen, X., Zhang, J. X., Luo, J. H., Wu, S., Yuan, G. J., Ma, N. F., ... & Xie, D. (2018). CSTF2-induced shortening of the RAC1 3′ UTR promotes the pathogenesis of urothelial carcinoma of the bladder. Cancer research, 78(20), 5848-5862.

Popow, J., Wieshofer, C., Schlattl, A., Woehrle, S., Neumüller, R., Petronczki, M. P., ... & Pearson, M. (2018). Synthetic lethality between CSTF2 and CSTF2T in lung adenocarcinoma and melanoma cell lines.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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