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Mouse Anti-CTDSP2 Recombinant Antibody (4F4) (V2LY-0125-LY240)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4F4
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant CTDSP2.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
Entrez Gene ID
10106
UniProt ID
O14595
Function
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.
Biological Process
IRE1-mediated unfolded protein response Source: Reactome
Negative regulation of G1/S transition of mitotic cell cycle Source: Ensembl
Negative regulation of protein phosphorylation Source: Ensembl
Protein dephosphorylation Source: UniProtKB
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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