Mouse Anti-CTNNBIP1 Recombinant Antibody (CBCNC-097) (V2LY-0125-LY329)

Name: Mouse Anti-CTNNBIP1 Recombinant Antibody (CBCNC-097)
SKU: V2LY-0125-LY329
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBCNC-097

Application

WB, IF, IHC

Immunogen

E. coli-derived recombinant human ICAT, Met1-Gln81.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal Antibody

Application Notes

Application	Note
IHC	5-25 μg/mL

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS & Trehalose

Preservative

None

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

catenin, beta interacting protein 1

Entrez Gene ID

56998

UniProt ID

Q9NSA3

Function

Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway.

Biological Process

Anterior/posterior pattern specification Source: Ensembl
Branching involved in ureteric bud morphogenesis Source: Ensembl
Negative regulation of DNA binding Source: Ensembl
Negative regulation of DNA-binding transcription factor activity Source: BHF-UCL
Negative regulation of mesenchymal cell proliferation Source: BHF-UCL
Negative regulation of protein binding Source: BHF-UCL
Negative regulation of protein-containing complex assembly Source: Ensembl
Negative regulation of smooth muscle cell proliferation Source: Ensembl
Negative regulation of transcription initiation from RNA polymerase II promoter Source: Ensembl
Negative regulation of Wnt signaling pathway Source: GO_Central
Positive regulation of monocyte differentiation Source: BHF-UCL
Positive regulation of osteoblast differentiation Source: BHF-UCL
Regulation of vascular permeability involved in acute inflammatory response Source: BHF-UCL
Wnt signaling pathway Source: UniProtKB-KW

Cellular Location

Cytoplasm; Nucleus

Liu, S., Liu, D., Liu, J., Liu, J., & Zhong, M. (2021). miR‐29a‐3p promotes migration and invasion in ameloblastoma via Wnt/β‐catenin signaling by targeting catenin beta interacting protein 1. Head & Neck, 43(12), 3911-3921.

Wang, C., Wang, H., Peng, Y., Zeng, B., Zhang, Y., Tang, X., ... & Yang, Z. (2021). CTNNBIP1 modulates keratinocyte proliferation through promoting the transcription of β‐catenin/TCF complex downstream genes. Journal of the European Academy of Dermatology and Venereology, 35(2), 368-379.

Zhang, Z., Jiang, W., Hu, M., Gao, R., & Zhou, X. (2021). MiR-486–3p promotes osteogenic differentiation of BMSC by targeting CTNNBIP1 and activating the Wnt/β-catenin pathway. Biochemical and Biophysical Research Communications, 566, 59-66.

Kosari‐Monfared, M., Nikbakhsh, N., Fattahi, S., Ghadami, E., Ranaei, M., Taheri, H., ... & Akhavan‐Niaki, H. (2019). CTNNBIP1 downregulation is associated with tumor grade and viral infections in gastric adenocarcinoma. Journal of cellular physiology, 234(3), 2895-2904.

Chang, J. M., Tsai, A. C. D., Huang, W. R., & Tseng, R. C. (2019). The alteration of CTNNBIP1 in lung cancer. International journal of molecular sciences, 20(22), 5684.

Bi, W., Huang, J., Nie, C., Liu, B., He, G., Han, J., ... & Zhang, J. (2018). CircRNA circRNA_102171 promotes papillary thyroid cancer progression through modulating CTNNBIP1-dependent activation of β-catenin pathway. Journal of Experimental & Clinical Cancer Research, 37(1), 1-9.

Fu, X., Zhu, X., Qin, F., Zhang, Y., Lin, J., Ding, Y., ... & Gao, Q. (2018). Linc00210 drives Wnt/β-catenin signaling activation and liver tumor progression through CTNNBIP1-dependent manner. Molecular cancer, 17(1), 1-14.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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