Rat Anti-CTSE Recombinant Antibody (CBFYC-2443) (V2LY-0125-LY426)

Name: Rat Anti-CTSE Recombinant Antibody (CBFYC-2443)
SKU: V2LY-0125-LY426
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBFYC-2443

Application

Immunogen

Mouse recombinant protein of Cathepsin E.

Host Species

Rat

Specificity

Mouse

Antibody Isotype

IgG2

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

0.5 mg/mL

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

cathepsin E

Entrez Gene ID

13034

UniProt ID

P70269

Function

May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.

Biological Process

Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: UniProtKB
Protein autoprocessing Source: Ensembl
Proteolysis Source: ARUK-UCL

Cellular Location

Endosome. The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome.

PTM

Glycosylated. The nature of the carbohydrate chain varies between cell types. In fibroblasts, the proenzyme contains a high mannose-type oligosaccharide, while the mature enzyme contains a complex-type oligosaccharide. In erythrocyte membranes, both the proenzyme and mature enzyme contain a complex-type oligosaccharide.
Two forms are produced by autocatalytic cleavage, form I begins at Ile-54, form II begins at Thr-57.

Zhu, Z., Wang, Q., Chen, X., Wang, Q., Yan, C., Zhao, X., ... & Zhu, W. H. (2022). An Enzyme‐Activatable Aggregation‐Induced‐Emission Probe: Intraoperative Pathological Fluorescent Diagnosis of Pancreatic Cancer via Specific Cathepsin E. Advanced Materials, 34(3), 2107444.

Wu, Y., Zhou, W., Yang, Z., Li, J., & Jin, Y. (2022). miR-185-5p Represses Cells Growth and Metastasis of Osteosarcoma via Targeting Cathepsin E. International Journal of Toxicology, 10915818211069270.

Kim, J. W., Cho, J. Y., Kim, J., Kim, D. G., Nam, B. H., Kim, Y. O., ... & Kong, H. J. (2020). First report of cathepsin E in a teleost (Korean rose bitterling, Rhodeus uyekii): Molecular characterisation and tissue distribution. Developmental & Comparative Immunology, 106, 103607.

Pontious, C., Kaul, S., Hong, M., Hart, P. A., Krishna, S. G., Lara, L. F., ... & Cruz-Monserrate, Z. (2019). Cathepsin E expression and activity: Role in the detection and treatment of pancreatic cancer. Pancreatology, 19(7), 951-956.

Hiramatsu, S., Watanabe, K. S., Zeggar, S., Asano, Y., Miyawaki, Y., Yamamura, Y., ... & Wada, J. (2019). Regulation of Cathepsin E gene expression by the transcription factor Kaiso in MRL/lpr mice derived CD4+ T cells. Scientific reports, 9(1), 1-13.

Mengwasser, J., Babes, L., Cordes, S., Mertlitz, S., Riesner, K., Shi, Y., ... & Penack, O. (2017). Cathepsin E deficiency ameliorates graft-versus-host disease and modifies dendritic cell motility. Frontiers in immunology, 8, 203.

Gonçalves, N. P., Moreira, J., Martins, D., Vieira, P., Obici, L., Merlini, G., ... & Saraiva, M. J. (2017). Differential expression of Cathepsin E in transthyretin amyloidosis: from neuropathology to the immune system. Journal of Neuroinflammation, 14(1), 1-12.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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