CTSE
The protein encoded by this gene is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease, which is a member of the peptidase C1 family, has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that does not appear to be involved in the digestion of dietary protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach. It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of gastric cancers. It appears, therefore, to be an oncofetal antigen. Transcript variants utilizing alternative polyadenylation signals and two transcript variants encoding different isoforms exist for this gene. [provided by RefSeq]
Full Name
cathepsin E
Function
May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.
Biological Process
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: UniProtKB
Protein autoprocessing Source: Ensembl
Proteolysis Source: ARUK-UCL
Protein autoprocessing Source: Ensembl
Proteolysis Source: ARUK-UCL
Cellular Location
Endosome. The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome.
PTM
Glycosylated. The nature of the carbohydrate chain varies between cell types. In fibroblasts, the proenzyme contains a high mannose-type oligosaccharide, while the mature enzyme contains a complex-type oligosaccharide. In erythrocyte membranes, both the proenzyme and mature enzyme contain a complex-type oligosaccharide.
Two forms are produced by autocatalytic cleavage, form I begins at Ile-54, form II begins at Thr-57.
Two forms are produced by autocatalytic cleavage, form I begins at Ile-54, form II begins at Thr-57.
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Anti-CTSE antibodies
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CompareTarget: CTSE
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2D5
Application*: WB, E
Target: CTSE
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 14L296
Application*: WB, IP, IF, E, P
Target: CTSE
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-398
Tag: His Tag
Target: CTSE
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-397
Tag: His Tag
Target: CTSE
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: C11318
Application*: WB
Target: CTSE
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBFYC-2443
Application*: WB
Target: CTSE
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBFYC-2442
Application*: WB
Target: CTSE
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 215
Application*: E
Target: CTSE
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: C6943
Application*: WB, IP, IF, E, P
Target: CTSE
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Mouse, Rat
Clone: C4903
Application*: WB, IP, IF, E
Target: CTSE
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: C11317
Application*: WB, IP, IF, E, P
Target: CTSE
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBXC-1013
Application*: WB, IP, IF, E, P
Target: CTSE
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-2446
Application*: WB, IP
Target: CTSE
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYC-2444
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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