Mouse Anti-CTSS Recombinant Antibody (1494) (V2LY-0125-LY472)

Name: Mouse Anti-CTSS Recombinant Antibody (1494)
SKU: V2LY-0125-LY472
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1494

Application

ELISA

Immunogen

Recombinant Human Cathepsin S Protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
ELISA	1:1,000-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Cathepsin S

Entrez Gene ID

1520

UniProt ID

P25774

Function

Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation (PubMed:30612035).

The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.

Biological Process

Adaptive immune response Source: UniProtKB
Antigen processing and presentation Source: UniProtKB
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: UniProtKB
Antigen processing and presentation of peptide antigen Source: CACAO
Basement membrane disassembly Source: BHF-UCL
Cellular response to thyroid hormone stimulus Source: UniProtKB
Collagen catabolic process Source: BHF-UCL
Extracellular matrix disassembly Source: Reactome
Immune response Source: GO_Central
Neutrophil degranulation Source: Reactome
Positive regulation of cation channel activity Source: CACAO
Protein processing Source: CACAO
Proteolysis Source: CAFA
Proteolysis involved in cellular protein catabolic process Source: BHF-UCL
Response to acidic pH Source: CACAO
Toll-like receptor signaling pathway Source: Reactome

Cellular Location

Secreted; Lysosome; Phagosome

Yoo, Y., Choi, E., Kim, Y., Cha, Y., Um, E., Kim, Y., ... & Lee, Y. S. (2022). Therapeutic potential of targeting cathepsin S in pulmonary fibrosis. Biomedicine & Pharmacotherapy, 145, 112245.

Bararia, D., Hildebrand, J. A., Stolz, S., Haebe, S., Alig, S., Trevisani, C. P., ... & Weigert, O. (2020). Cathepsin S alterations induce a tumor-promoting immune microenvironment in follicular lymphoma. Cell reports, 31(5), 107522.

Brown, R., Nath, S., Lora, A., Samaha, G., Elgamal, Z., Kaiser, R., ... & Geraghty, P. (2020). Cathepsin S: investigating an old player in lung disease pathogenesis, comorbidities, and potential therapeutics. Respiratory Research, 21(1), 1-17.

Ni, H., Xu, S., Chen, H., & Dai, Q. (2020). Nicotine modulates CTSS (cathepsin S) synthesis and secretion through regulating the autophagy-lysosomal machinery in atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 40(9), 2054-2069.

Lai, C. H., Chang, J. Y., Wang, K. C., Lee, F. T., Wu, H. L., & Cheng, T. L. (2020). Pharmacological inhibition of cathepsin S suppresses abdominal aortic aneurysm in mice. European Journal of Vascular and Endovascular Surgery, 59(6), 990-999.

Doherty, D. F., Nath, S., Poon, J., Foronjy, R. F., Ohlmeyer, M., Dabo, A. J., ... & Geraghty, P. (2019). Protein phosphatase 2A reduces cigarette smoke–induced cathepsin S and loss of lung function. American journal of respiratory and critical care medicine, 200(1), 51-62.

Kim, S., Jin, H., Seo, H. R., Lee, H. J., & Lee, Y. S. (2019). Regulating BRCA1 protein stability by cathepsin S-mediated ubiquitin degradation. Cell Death & Differentiation, 26(5), 812-825.

Wilkinson, R. D., Burden, R. E., McDowell, S. H., McArt, D. G., McQuaid, S., Bingham, V., ... & Scott, C. J. (2019). A novel role for cathepsin S as a potential biomarker in triple negative breast cancer. Journal of Oncology, 2019.

Edman, M. C., Janga, S. R., Meng, Z., Bechtold, M., Chen, A. F., Kim, C., ... & Hamm-Alvarez, S. F. (2018). Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjögren’s Syndrome patients. Scientific reports, 8(1), 1-12.

Tan, J., Qian, X., Song, B., An, X., Cai, T., Zuo, Z., ... & Li, H. (2018). Integrated bioinformatics analysis reveals that the expression of cathepsin S is associated with lymph node metastasis and poor prognosis in papillary thyroid cancer. Oncology reports, 40(1), 111-122.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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