Rat Anti-CX3CL1 Recombinant Antibody (CBFYC-0248) (V2LY-0125-LY571)

C-X3-C Motif Chemokine Ligand 1

Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1 (PubMed:9782118, PubMed:12055230, PubMed:23125415, PubMed:9931005, PubMed:21829356).

The CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis (PubMed:9024663, PubMed:9177350, PubMed:9782118, PubMed:12055230).

Regulates leukocyte adhesion and migration processes at the endothelium (PubMed:9024663, PubMed:9177350).

Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner (PubMed:23125415, PubMed:24789099).

In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins (PubMed:23125415, PubMed:24789099).

In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (PubMed:23125415, PubMed:24789099).

Processed fractalkine:
The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils.

Fractalkine:
The membrane-bound form promotes adhesion of those leukocytes to endothelial cells.

Aging Source: ARUK-UCL
Autocrine signaling Source: ARUK-UCL
Cell adhesion Source: ARUK-UCL
Cell-cell adhesion Source: ARUK-UCL
Cell-cell signaling Source: ARUK-UCL
Cell chemotaxis Source: ARUK-UCL
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: ARUK-UCL
Chemotaxis Source: UniProtKB
Cytokine-mediated signaling pathway Source: UniProtKB
Defense response Source: UniProtKB
Eosinophil chemotaxis Source: GO_Central
G protein-coupled receptor signaling pathway Source: ARUK-UCL
Immune response Source: UniProtKB
Inflammatory response Source: GO_Central
Integrin activation Source: UniProtKB
Leukocyte adhesive activation Source: UniProtKB
Leukocyte chemotaxis Source: UniProtKB
Leukocyte migration involved in inflammatory response Source: UniProtKB
Lymphocyte chemotaxis Source: GO_Central
Microglial cell activation Source: ARUK-UCL
Microglial cell proliferation Source: ARUK-UCL
Monocyte chemotaxis Source: GO_Central
Negative regulation of apoptotic process Source: ARUK-UCL
Negative regulation of apoptotic signaling pathway Source: ARUK-UCL
Negative regulation of cell migration Source: BHF-UCL
Negative regulation of cell-substrate adhesion Source: ARUK-UCL
Negative regulation of glutamate receptor signaling pathway Source: ARUK-UCL
Negative regulation of hippocampal neuron apoptotic process Source: ARUK-UCL
Negative regulation of interleukin-1 alpha production Source: ARUK-UCL
Negative regulation of interleukin-1 beta production Source: ARUK-UCL
Negative regulation of interleukin-6 production Source: ARUK-UCL
Negative regulation of microglial cell activation Source: ARUK-UCL
Negative regulation of neuron migration Source: ARUK-UCL
Negative regulation of tumor necrosis factor production Source: ARUK-UCL
Neuron cellular homeostasis Source: ARUK-UCL
Neuron remodeling Source: ARUK-UCL
Neutrophil chemotaxis Source: GO_Central
Positive chemotaxis Source: ARUK-UCL
Positive regulation of actin filament bundle assembly Source: ARUK-UCL
Positive regulation of calcium-independent cell-cell adhesion Source: UniProtKB
Positive regulation of cell-matrix adhesion Source: ARUK-UCL
Positive regulation of cell population proliferation Source: ARUK-UCL
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: ARUK-UCL
Positive regulation of I-kappaB phosphorylation Source: ARUK-UCL
Positive regulation of inflammatory response Source: UniProtKB
Positive regulation of MAPK cascade Source: ARUK-UCL
Positive regulation of microglial cell migration Source: ARUK-UCL
Positive regulation of neuroblast proliferation Source: ARUK-UCL
Positive regulation of neuron projection development Source: ARUK-UCL
Positive regulation of NF-kappaB transcription factor activity Source: ARUK-UCL
Positive regulation of protein kinase B signaling Source: ARUK-UCL
Positive regulation of release of sequestered calcium ion into cytosol Source: ARUK-UCL
Positive regulation of smooth muscle cell proliferation Source: ARUK-UCL
Positive regulation of transcription by RNA polymerase II Source: ARUK-UCL
Regulation of lipopolysaccharide-mediated signaling pathway Source: ARUK-UCL
Regulation of neurogenesis Source: ARUK-UCL
Regulation of synaptic plasticity Source: ARUK-UCL
Response to ischemia Source: ARUK-UCL
Synapse pruning Source: ARUK-UCL

Cell membrane
Processed fractalkine: Secreted

Extracellular: 25-341
Helical: 342-362
Cytoplasmic: 363-397

A soluble short 95 kDa form may be released by proteolytic cleavage from the long membrane-anchored form.
O-glycosylated with core 1 or possibly core 8 glycans.