Mouse Anti-CXCL16 Recombinant Antibody (CBFYC-0480) (V2LY-0125-LY676)

Name: Mouse Anti-CXCL16 Recombinant Antibody (CBFYC-0480)
SKU: V2LY-0125-LY676
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYC-0480

Application

ELISA

Immunogen

Recombinant Rat CXCL16 / SR-PSOX protein.

Host Species

Mouse

Specificity

Rat

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
ELISA	1:1,000-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

C-X-C Motif Chemokine Ligand 16

Entrez Gene ID

497942

UniProt ID

Q6AXU5

Function

Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity).

Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.

Biological Process

Chemotaxis Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Positive regulation of cell growth Source: BHF-UCL
Positive regulation of cell migration Source: BHF-UCL
Receptor-mediated endocytosis Source: UniProtKB
Response to cytokine Source: BHF-UCL
Response to interferon-gamma Source: BHF-UCL
Response to tumor necrosis factor Source: BHF-UCL
T cell chemotaxis Source: GO_Central

Cellular Location

Cell membrane; Secreted. Also exists as a soluble form.

Topology

Extracellular: 30-205
Helical: 206-226
Cytoplasmic: 227-254

PTM

Glycosylated.

Liu, W., Wang, L., Li, X., Gao, C., Zhou, J., Zhou, J., ... & Yang, J. (2021). CXC Motif Chemokine Ligand 16 Is a Potent Predictor of Outcomes in Dialysis Patients. American Journal of Nephrology, 52(9), 725-734.

Gong, Y., Li, J., Huang, L., Liu, Y., & Cao, J. (2022). Prognostic and pathogenic role of CXC Motif Ligand 16 in sepsis. Microbes and infection, 24(1), 104882.

Shabgah, A. G., Qasim, M. T., Mostafavi, S. M., Zekiy, A. O., Ezzatifar, F., Ahmadi, M., ... & Navashenaq, J. G. (2021). CXC chemokine ligand 16: a Swiss army knife chemokine in cancer. Expert Reviews in Molecular Medicine, 23.

Ma, Z., Ma, C., Zhang, Q., Bai, Y., Mu, K., Liu, X., & Yang, Q. (2021). Role of CXCL16 in BLM-induced epithelial–mesenchymal transition in human A549 cells. Respiratory research, 22(1), 1-10.

Han, J., Fu, R., Chen, C., Cheng, X., Guo, T., Huangfu, L., ... & Ji, J. (2021). CXCL16 Promotes Gastric Cancer Tumorigenesis via ADAM10-Dependent CXCL16/CXCR6 Axis and Activates Akt and MAPK Signaling Pathways. International journal of biological sciences, 17(11), 2841.

Schranz, D., Molnar, T., Erdo-Bonyar, S., Simon, D., Berki, T., Zavori, L., ... & Csecsei, P. (2021). Fatty Acid-Binding Protein 3 and CXC-Chemokine Ligand 16 are Associated with Unfavorable Outcome in Aneurysmal Subarachnoid Hemorrhage. Journal of Stroke and Cerebrovascular Diseases, 30(11), 106068.

Juárez-Rodríguez, P., Godínez-Rubí, M., Guzmán-Brambila, C., Padilla-Velarde, E., Orozco-Barocio, A., Ortuño-Sahagún, D., & Rojas-Mayorquín, A. E. (2020). Prenatal alcohol exposure in rats diminishes postnatal cxcl16 chemokine ligand brain expression. Brain sciences, 10(12), 987.

Andersen, T., Ueland, T., Ghukasyan Lakic, T., Åkerblom, A., Bertilsson, M., Aukrust, P., ... & PLATO Investigators. (2019). CXC ligand 16 is an independent predictor of cardiovascular death and morbidity in acute coronary syndromes. Arteriosclerosis, Thrombosis, and Vascular Biology, 39(11), 2402-2410.

Liang, K., Liu, Y., Eer, D., Liu, J., Yang, F., & Hu, K. (2018). High CXC chemokine ligand 16 (CXCL16) expression promotes proliferation and metastasis of lung cancer via regulating the NF-κB pathway. Medical science monitor: international medical journal of experimental and clinical research, 24, 405.

Lang, K., Bonberg, N., Robens, S., Behrens, T., Hovanec, J., Deix, T., ... & Brüning, T. (2017). Soluble chemokine (CXC motif) ligand 16 (CXCL16) in urine as a novel biomarker candidate to identify high grade and muscle invasive urothelial carcinomas. Oncotarget, 8(62), 104946.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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