Mouse Anti-CXCL8 Recombinant Antibody (6D12) (V2LY-0125-LY731)

C-X-C motif chemokine ligand 8

IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.

Angiogenesis Source: UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Calcium-mediated signaling Source: UniProtKB
Cell cycle arrest Source: UniProtKB
Cellular response to fibroblast growth factor stimulus Source: UniProtKB
Cellular response to interleukin-1 Source: UniProtKB
Cellular response to lipopolysaccharide Source: BHF-UCL
Cellular response to tumor necrosis factor Source: UniProtKB
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: UniProtKB
Cytokine-mediated signaling pathway Source: Reactome
Embryonic digestive tract development Source: DFLAT
G protein-coupled receptor signaling pathway Source: Reactome
Induction of positive chemotaxis Source: UniProtKB
Inflammatory response Source: GO_Central
Intracellular signal transduction Source: UniProtKB
Killing of cells of other organism Source: UniProtKB
Negative regulation of cell adhesion molecule production Source: ARUK-UCL
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of gene expression Source: ARUK-UCL
Negative regulation of G protein-coupled receptor signaling pathway Source: UniProtKB
Neutrophil activation Source: UniProtKB
Neutrophil chemotaxis Source: UniProtKB
PERK-mediated unfolded protein response Source: Reactome
Positive regulation of angiogenesis Source: CACAO
Positive regulation of cellular biosynthetic process Source: ARUK-UCL
Positive regulation of gene expression Source: ARUK-UCL
Positive regulation of neutrophil chemotaxis Source: BHF-UCL
Receptor internalization Source: UniProtKB
Regulation of cell adhesion Source: UniProtKB
Regulation of entry of bacterium into host cell Source: AgBase
Regulation of single stranded viral RNA replication via double stranded DNA intermediate Source: UniProtKB
Response to endoplasmic reticulum stress Source: UniProtKB
Response to molecule of bacterial origin Source: BHF-UCL
Signal transduction Source: ProtInc

Secreted

Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form.
Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.