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Mouse Anti-CYCS Recombinant Antibody (CBXC-2298) (CBMAB-C0324-CQ)


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Published Data
CBMAB-C0324-CQ-1
Mouse Anti-CYCS Recombinant Antibody (CBXC-2298) (CBMAB-C0324-CQ) in WB
The HepG2 liver cancer cells were treated with DOX (2 μg/mL) and SS-b2 (40, 80 mg/L) for 24 h and then subjected to western blot analysis. Representative western blot photograph. ...View More
Zhu, Y., Lv, X., Li, R., Gao, Z., Lei, C., Wang, L., & Li, S. (2024). Saikosaponin-b2 Regulates the Proliferation and Apoptosis of Liver Cancer Cells by Targeting the MACC1/c-Met/Akt Signalling Pathway. Advances in Pharmacological and Pharmaceutical Sciences, 2024(1), 2653426. Distributed under Open Access license CC BY 4.0, without modification.
CBMAB-C0324-CQ-2
Mouse Anti-CYCS Recombinant Antibody (CBXC-2298) (CBMAB-C0324-CQ) in IHC
Immunostaining of anti-bax, anti-Bcl2, and anti-cytochrome c antibodies in the liver of experimental groups. 40x objective. 50μm calibration bar. ...View More
Lontro Alves, L., Gomes Pereira, P., Torres Ciambarella, B., Porto Campos, M., Rabelo, K., Rosa Nascimento, A. L., ... & José de Carvalho, J. (2024). Beneficial Effects of Capybara Oil Supplementation on Steatosis and Liver Apoptosis in Obese Mice. Journal of Obesity, 2024(1), 7204607. Distributed under Open Access license CC BY 4.0, without modification.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Horse
Clone
CBXC-2298
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA, FC, IHC-P

Basic Information

Immunogen
Amino acids 1-104 of horse cytochrome c.
Host Species
Mouse
Specificity
Human, Mouse, Rat, Horse
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:100-1:1,000
WB1:100-1:1,000
IP1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)
IF(ICC)1:50-1:500
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml

Target

Full Name
Cytochrome C, Somatic
Entrez Gene ID
Human54205
Mouse13063
Rat25309
UniProt ID
HumanP99999
MouseP62897
RatP62898
Alternative Names
Cytochrome C, Somatic; CYC; Cytochrome C; THC4; HCS;
Function
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Source: UniProtKB
Apoptotic process Source: UniProtKB-KW
Cellular respiration Source: UniProtKB
Cellular response to oxidative stress Source: Reactome
Mitochondrial electron transport, cytochrome c to oxygen Source: GO_Central
Mitochondrial electron transport, ubiquinol to cytochrome c Source: GO_Central
Mitochondrion organization Source: Reactome
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
Cellular Location
Mitochondrion intermembrane space. Loosely associated with the inner membrane.
Involvement in disease
Thrombocytopenia 4 (THC4):
A form of thrombocytopenia, a hematologic disorder defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting.
PTM
Binds 1 heme group per subunit.
Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.
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For research use only. Not intended for any clinical use.

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