Mouse Anti-CYP1A2 Recombinant Antibody (CBXC-2435) (CBMAB-C3993-CQ)

Cytochrome P450 Family 1 Subfamily A Member 2

A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:9435160, PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576).

Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:9435160, PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576).

Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:11555828, PubMed:12865317).

Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2 (PubMed:11555828, PubMed:12865317).

Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599).

May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376).

Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer (PubMed:19965576).

Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA (PubMed:9435160).

May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195).

Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin (PubMed:14725854).

Metabolizes caffeine via N3-demethylation (Probable).

Aflatoxin metabolic process Source: Reactome
Alkaloid metabolic process Source: BHF-UCL
Cellular respiration Source: Ensembl
Cellular response to cadmium ion Source: Ensembl
Cellular response to copper ion Source: Ensembl
Cholesterol metabolic process Source: UniProtKB-UniPathway
Dibenzo-p-dioxin metabolic process Source: Ensembl
Drug catabolic process Source: BHF-UCL
Drug metabolic process Source: BHF-UCL
Epoxygenase P450 pathway Source: Reactome
Estrogen metabolic process Source: UniProtKB
Exogenous drug catabolic process Source: BHF-UCL
Heterocycle metabolic process Source: BHF-UCL
Hydrogen peroxide biosynthetic process Source: Ensembl
Long-chain fatty acid biosynthetic process Source: Reactome
Lung development Source: Ensembl
Methylation Source: Reactome
Monocarboxylic acid metabolic process Source: BHF-UCL
Monoterpenoid metabolic process Source: BHF-UCL
Omega-hydroxylase P450 pathway Source: Reactome
Oxidative demethylation Source: BHF-UCL
Porphyrin-containing compound metabolic process Source: Ensembl
Post-embryonic development Source: Ensembl
Regulation of gene expression Source: Ensembl
Response to estradiol Source: Ensembl
Response to immobilization stress Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Retinol metabolic process Source: UniProtKB
Steroid catabolic process Source: BHF-UCL
Toxin biosynthetic process Source: BHF-UCL
Xenobiotic metabolic process Source: Reactome

Endoplasmic reticulum membrane; Microsome membrane