CYP1A2

CYP1A2 (Cytochrome P450 Family 1 Subfamily A Member 2) is a Protein Coding gene. Diseases associated with CYP1A2 include Toxicity Or Absent Response To Clozapine and Acetaminophen Metabolism. Among its related pathways are Gefitinib Pathway, Pharmacokinetics and Estrogen Receptor Pathway. Gene Ontology (GO) annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP1A1.

Cytochrome P450 Family 1 Subfamily A Member 2

A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:9435160, PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576).

Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:9435160, PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576).

Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:11555828, PubMed:12865317).

Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2 (PubMed:11555828, PubMed:12865317).

Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599).

May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376).

Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer (PubMed:19965576).

Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA (PubMed:9435160).

May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195).

Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin (PubMed:14725854).

Metabolizes caffeine via N3-demethylation (Probable).

Aflatoxin metabolic process Source: Reactome
Alkaloid metabolic process Source: BHF-UCL
Cellular respiration Source: Ensembl
Cellular response to cadmium ion Source: Ensembl
Cellular response to copper ion Source: Ensembl
Cholesterol metabolic process Source: UniProtKB-UniPathway
Dibenzo-p-dioxin metabolic process Source: Ensembl
Drug catabolic process Source: BHF-UCL
Drug metabolic process Source: BHF-UCL
Epoxygenase P450 pathway Source: Reactome
Estrogen metabolic process Source: UniProtKB
Exogenous drug catabolic process Source: BHF-UCL
Heterocycle metabolic process Source: BHF-UCL
Hydrogen peroxide biosynthetic process Source: Ensembl
Long-chain fatty acid biosynthetic process Source: Reactome
Lung development Source: Ensembl
Methylation Source: Reactome
Monocarboxylic acid metabolic process Source: BHF-UCL
Monoterpenoid metabolic process Source: BHF-UCL
Omega-hydroxylase P450 pathway Source: Reactome
Oxidative demethylation Source: BHF-UCL
Porphyrin-containing compound metabolic process Source: Ensembl
Post-embryonic development Source: Ensembl
Regulation of gene expression Source: Ensembl
Response to estradiol Source: Ensembl
Response to immobilization stress Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Retinol metabolic process Source: UniProtKB
Steroid catabolic process Source: BHF-UCL
Toxin biosynthetic process Source: BHF-UCL
Xenobiotic metabolic process Source: Reactome

Endoplasmic reticulum membrane; Microsome membrane