Sign in or Register   Sign in or Register
  |  

Rabbit Anti-DAGLB Recombinant Antibody (D4P7C) (CBMAB-D0183-YC)

Provided herein is a Rabbit monoclonal antibody, which binds to Diacylglycerol Lipase Beta (DAGLB). The antibody can be used for immunoassay techniques, such as WB, IP.
See all DAGLB antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
D4P7C
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Diacylglycerol Lipase Beta
Introduction
DAGLB (Diacylglycerol Lipase Beta) is a protein coding gene. Diseases associated with DAGLB include Hallucinogen Dependence. Among its related pathways are N-cadherin signaling events and Response to elevated platelet cytosolic Ca2+. The protein has hydrolase activity and lipase activity and the paralog is DAGLA.
Entrez Gene ID
Human221955
Mouse231871
Rat304289
Monkey717799
UniProt ID
HumanQ8NCG7
MouseQ91WC9
RatP0C1S9
MonkeyF6T9G9
Alternative Names
Diacylglycerol Lipase Beta; DGL-Beta; KCCR13L; Sn1-Specific Diacylglycerol Lipase Beta; Diacylglycerol Lipase, Beta; EC 3.1.1.-; DAGLBETA;
Function
Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:14610053).

Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053).

Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Functions also as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages (By similarity).
Biological Process
Arachidonic acid metabolic process Source: UniProtKB
Endocannabinoid signaling pathway Source: GO_Central
G protein-coupled glutamate receptor signaling pathway Source: GO_Central
Lipid catabolic process Source: UniProtKB-KW
Neuroblast proliferation Source: Ensembl
Neurogenesis Source: GO_Central
Neurotransmitter biosynthetic process Source: GO_Central
Positive regulation of triglyceride catabolic process Source: UniProtKB
Prostaglandin biosynthetic process Source: UniProtKB
Regulation of inflammatory response Source: UniProtKB
Retrograde trans-synaptic signaling by endocannabinoid Source: GO_Central
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-17
Helical: 18-38
Extracellular: 39-58
Helical: 59-79
Cytoplasmic: 80-102
Helical: 103-123
Extracellular: 124-132
Helical: 133-153
Cytoplasmic: 154-672
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-DAGLB Recombinant Antibody (D4P7C)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare