DAGLB

DAGLB (Diacylglycerol Lipase Beta) is a Protein Coding gene. Diseases associated with DAGLB include Hallucinogen Dependence. Among its related pathways are N-cadherin signaling events and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include hydrolase activity and lipase activity. An important paralog of this gene is DAGLA.

Full Name

Diacylglycerol Lipase Beta

Function

Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:14610053).

Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053).

Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Functions also as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages (By similarity).

Biological Process

Arachidonic acid metabolic process Source: UniProtKB
Endocannabinoid signaling pathway Source: GO_Central
G protein-coupled glutamate receptor signaling pathway Source: GO_Central
Lipid catabolic process Source: UniProtKB-KW
Neuroblast proliferation Source: Ensembl
Neurogenesis Source: GO_Central
Neurotransmitter biosynthetic process Source: GO_Central
Positive regulation of triglyceride catabolic process Source: UniProtKB
Prostaglandin biosynthetic process Source: UniProtKB
Regulation of inflammatory response Source: UniProtKB
Retrograde trans-synaptic signaling by endocannabinoid Source: GO_Central

Cellular Location

Cell membrane

Topology

Cytoplasmic: 1-17
Helical: 18-38
Extracellular: 39-58
Helical: 59-79
Cytoplasmic: 80-102
Helical: 103-123
Extracellular: 124-132
Helical: 133-153
Cytoplasmic: 154-672