Mouse Anti-DAPP1 Recombinant Antibody (CBYCD-149) (V2LY-0125-LY1107)

Name: Mouse Anti-DAPP1 Recombinant Antibody (CBYCD-149)
SKU: V2LY-0125-LY1107
Rating: 5 (1 reviews)

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Summary

Host Animal

Mouse

Specificity

Human, Mouse

Clone

CBYCD-149

Antibody Isotype

IgG2a

Application

Basic Information

Immunogen

E. coli-derived recombinant human DAPP1, Gly2-Ser163.

Host Species

Mouse

Specificity

Human, Mouse

Antibody Isotype

IgG2a

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1 μg/mL

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS & Trehalose

Preservative

None

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Dual Adaptor Of Phosphotyrosine And 3-Phosphoinositides 1

Entrez Gene ID

Human	27071
Mouse	26377

UniProt ID

Human	Q9UN19
Mouse	Q9QXT1

Function

May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K.

Biological Process

Protein dephosphorylation Source: UniProtKB
Signal transduction Source: ProtInc

Cellular Location

Cytoplasm; Membrane. Membrane-associated after cell stimulation leading to its translocation.

PTM

Phosphorylated on tyrosine residues.

More Infomation

References

Chen, S., Qi, Y., Wang, S., Xu, Y., Shen, M., Hu, M., ... & Wang, J. (2020). Melatonin enhances thrombopoiesis through ERK1/2 and Akt activation orchestrated by dual adaptor for phosphotyrosine and 3‐phosphoinositides. Journal of Pineal Research, 68(3), e12637.

Hao, L., Marshall, A. J., & Liu, L. (2020). Bam32/DAPP1-dependent neutrophil reactive oxygen species in WKYMVm-induced microvascular hyperpermeability. Frontiers in Immunology, 11, 1028.

Durrant, T. N., Hutchinson, J. L., Heesom, K. J., Anderson, K. E., Stephens, L. R., Hawkins, P. T., ... & Hers, I. (2017). In-depth PtdIns (3, 4, 5) P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function. Blood advances, 1(14), 918-932.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

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