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Mouse Anti-DCD Recombinant Antibody (13A43) (CBMAB-D0335-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Dermcidin (DCD). The antibody can be used for immunoassay techniques, such as ELISA, IHC, WB.
See all DCD antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
13A43
Antibody Isotype
IgM
Application
ELISA, IHC, WB

Basic Information

Immunogen
Fractioned sweat peptides in complete Freunds adjuvant
Specificity
Human
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dermcidin
Introduction
DCD is a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients.
Entrez Gene ID
117159
UniProt ID
P81605
Alternative Names
Dermcidin; Preproteolysin; Diffusible Survival/Evasion Peptide; Proteolysis Inducing Factor; Survival Promoting Peptide; AIDD;
Function
DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues (PubMed:17448443).

Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG.
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Antimicrobial humoral response Source: Reactome
Defense response to bacterium Source: UniProtKB-KW
Defense response to fungus Source: UniProtKB
Defense response to Gram-negative bacterium Source: UniProtKB
Defense response to Gram-positive bacterium Source: UniProtKB
Killing by host of symbiont cells Source: CACAO
Killing of cells of other organism Source: UniProtKB
Cellular Location
Secreted

Farshadzadeh, Z., Pourhajibagher, M., Taheri, B., Ekrami, A., Modarressi, M. H., Azimzadeh, M., & Bahador, A. (2022). Antimicrobial and anti-biofilm potencies of dermcidin-derived peptide DCD-1L against Acinetobacter baumannii: an in vivo wound healing model. BMC microbiology, 22(1), 1-13.

Qiu, F., Long, H., Zhang, L., Liu, J., Yang, Z., & Huang, X. (2022). Dermcidin Enhances the Migration, Invasion, and Metastasis of Hepatocellular Carcinoma Cells In Vitro and In Vivo. Journal of Clinical and Translational Hepatology, (000), 0-0.

Lager, T. W., Conner, C., Keating, C. R., Warshaw, J. N., & Panopoulos, A. D. (2021). Cell surface Grp78 and dermcidin cooperate to regulate breast cancer cell migration through Wnt signaling. Oncogene, 40(23), 4050-4059.

Alatas, E. T., Kara Polat, A., Kalayci, M., Dogan, G., & Akin Belli, A. (2019). Plasma dermcidin levels in acne patients, and the effect of isotretinoin treatment on dermcidin levels. Dermatologic Therapy, 32(5), e13044.

Song, C., de Groot, B. L., & Sansom, M. S. (2019). Lipid bilayer composition influences the activity of the antimicrobial peptide dermcidin channel. Biophysical journal, 116(9), 1658-1666.

Qiu, F., Qiu, F., Liu, L., Liu, J., Xu, J., & Huang, X. (2018). The Role of dermcidin in the diagnosis and staging of hepatocellular carcinoma. Genetic Testing and Molecular Biomarkers, 22(4), 218-223.

Mohanraj, U., Kinnunen, O., Kaya, M. E., Aranko, A. S., Viskari, H., & Linder, M. (2018). SUMO-based expression and purification of dermcidin-derived DCD-1L, a human antimicrobial peptide, in Escherichia coli. BioRxiv, 343418.

Nguyen, V. S., Tan, K. W., Ramesh, K., Chew, F. T., & Mok, Y. K. (2017). Structural basis for the bacterial membrane insertion of dermcidin peptide, DCD-1L. Scientific reports, 7(1), 1-11.

Zeth, K., & Sancho-Vaello, E. (2017). The human antimicrobial peptides dermcidin and LL-37 show novel distinct pathways in membrane interactions. Frontiers in chemistry, 5, 86.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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