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Mouse Anti-DCP2 Antibody (1D6) (CBMAB-0279-YC)

Provided herein are mouse monoclonal antibodies against Human DCP2. The antibody clone 1D6 can be used for immunoassay techniques, such as IP and MA.
See all DCP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1D6
Antibody Isotype
IgG2a
Application
IP, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DCP2
Introduction
DCP2 (decapping mRNA 2) is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). DCP2 is required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end.
Entrez Gene ID
167227
UniProt ID
Q8IU60
Alternative Names
NUDT20
Function
Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:12417715, PubMed:12218187, PubMed:12923261, PubMed:21070968, PubMed:28002401).

Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12486012, PubMed:12923261, PubMed:21070968, PubMed:28002401).

Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:14527413).

Plays a role in replication-dependent histone mRNA degradation (PubMed:18172165).

Has higher activity towards mRNAs that lack a poly(A) tail (PubMed:21070968).

Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968).

The presence of a N6-methyladenosine methylation at the second transcribed position of mRNAs (N6,2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping (PubMed:28002401).

Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573).
Biological Process
Deadenylation-dependent decapping of nuclear-transcribed mRNA Source: GO_Central
Exonucleolytic catabolism of deadenylated mRNA Source: Reactome
Histone mRNA catabolic process Source: UniProtKB
mRNA catabolic process Source: UniProtKB
Negative regulation of telomere maintenance via telomerase Source: BHF-UCL
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB-KW
Regulation of mRNA stability Source: UniProtKB
Regulation of telomerase RNA localization to Cajal body Source: BHF-UCL
Cellular Location
Nucleus; P-body. Predominantly cytoplasmic, in processing bodies (PB) (PubMed:15273322). A minor amount is nuclear (PubMed:15273322).
PTM
Phosphorylated at ser-249 in a MTOR-dependent manner (PubMed:26098573).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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