Mouse Anti-DDR1 Recombinant Antibody (CBYY-C2410) (CBMAB-C3848-YY)
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Target
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Basic Information
Host Animal
Mouse
Clone
CBYY-C2410
Application
WB, IP, IF, IHC-P, FC
Immunogen
Human CD167a/DDR1.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgM, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
| Application | Note |
| WB | 1:100-1:1,000 |
| IP | 1-2 µg per 100-500 µg of total protein (1 ml of cell lysate) |
| IF(ICC) | 1:50-1:500 |
| IHC-P | 1:50-1:500 |
Formulations & Storage [For reference only, actual COA shall prevail!]
Format
Liquid
Buffer
Gelatin & PBS
Preservative
Sodium Azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation
Target
Full Name
Discoidin Domain Receptor Tyrosine Kinase 1
Entrez Gene ID
UniProt ID
Alternative Names
Erb-B2 Receptor Tyrosine Kinase 3; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3; Tyrosine Kinase-Type Cell Surface Receptor HER3; Human Epidermal Growth Factor Receptor 3; Proto-Oncogene-Like Protein C-ErbB-3; EC 2.7.10.1; HER3; Lethal Congenital Contracture Syndrome 2; Receptor Tyrosine-Protein Kinase ErbB-3; P180-ErbB3;
Function
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity).
Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
Biological Process
Axon development Source: Ensembl
Branching involved in mammary gland duct morphogenesis Source: Ensembl
Cell adhesion Source: ProtInc
Collagen-activated tyrosine kinase receptor signaling pathway Source: UniProtKB
Ear development Source: Ensembl
Embryo implantation Source: Ensembl
Extracellular matrix organization Source: Reactome
Lactation Source: UniProtKB-KW
Mammary gland alveolus development Source: Ensembl
Multicellular organism development Source: GO_Central
Negative regulation of cell population proliferation Source: Ensembl
Neuron projection extension Source: Ensembl
Peptidyl-tyrosine autophosphorylation Source: UniProtKB
Positive regulation of kinase activity Source: GO_Central
Protein autophosphorylation Source: UniProtKB
Regulation of cell growth Source: Ensembl
Regulation of cell-matrix adhesion Source: Ensembl
Regulation of extracellular matrix disassembly Source: UniProtKB
Smooth muscle cell-matrix adhesion Source: UniProtKB
Smooth muscle cell migration Source: UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Wound healing, spreading of cells Source: UniProtKB
Branching involved in mammary gland duct morphogenesis Source: Ensembl
Cell adhesion Source: ProtInc
Collagen-activated tyrosine kinase receptor signaling pathway Source: UniProtKB
Ear development Source: Ensembl
Embryo implantation Source: Ensembl
Extracellular matrix organization Source: Reactome
Lactation Source: UniProtKB-KW
Mammary gland alveolus development Source: Ensembl
Multicellular organism development Source: GO_Central
Negative regulation of cell population proliferation Source: Ensembl
Neuron projection extension Source: Ensembl
Peptidyl-tyrosine autophosphorylation Source: UniProtKB
Positive regulation of kinase activity Source: GO_Central
Protein autophosphorylation Source: UniProtKB
Regulation of cell growth Source: Ensembl
Regulation of cell-matrix adhesion Source: Ensembl
Regulation of extracellular matrix disassembly Source: UniProtKB
Smooth muscle cell-matrix adhesion Source: UniProtKB
Smooth muscle cell migration Source: UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Wound healing, spreading of cells Source: UniProtKB
Cellular Location
Isoform 1&2&4: Cell membrane
Isoform 3: Secreted
Isoform 3: Secreted
Topology
Extracellular: 21-417
Helical: 418-438
Cytoplasmic: 439-913
Helical: 418-438
Cytoplasmic: 439-913
PTM
Autophosphorylated in response to fibrillar collagen binding.
Glycosylation of Asn-211, but apparently not of Asn-260 or Asn-394, prevents autophosphorylation from occurring in the absence of collagen.
Glycosylation of Asn-211, but apparently not of Asn-260 or Asn-394, prevents autophosphorylation from occurring in the absence of collagen.
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For research use only. Not intended for any clinical use.
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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