DDR1

Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

Discoidin Domain Receptor Tyrosine Kinase 1

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity).

Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.

Axon development Source: Ensembl
Branching involved in mammary gland duct morphogenesis Source: Ensembl
Cell adhesion Source: ProtInc
Collagen-activated tyrosine kinase receptor signaling pathway Source: UniProtKB
Ear development Source: Ensembl
Embryo implantation Source: Ensembl
Extracellular matrix organization Source: Reactome
Lactation Source: UniProtKB-KW
Mammary gland alveolus development Source: Ensembl
Multicellular organism development Source: GO_Central
Negative regulation of cell population proliferation Source: Ensembl
Neuron projection extension Source: Ensembl
Peptidyl-tyrosine autophosphorylation Source: UniProtKB
Positive regulation of kinase activity Source: GO_Central
Protein autophosphorylation Source: UniProtKB
Regulation of cell growth Source: Ensembl
Regulation of cell-matrix adhesion Source: Ensembl
Regulation of extracellular matrix disassembly Source: UniProtKB
Smooth muscle cell-matrix adhesion Source: UniProtKB
Smooth muscle cell migration Source: UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Wound healing, spreading of cells Source: UniProtKB

Isoform 1&2&4: Cell membrane
Isoform 3: Secreted

Extracellular: 21-417
Helical: 418-438
Cytoplasmic: 439-913

Autophosphorylated in response to fibrillar collagen binding.
Glycosylation of Asn-211, but apparently not of Asn-260 or Asn-394, prevents autophosphorylation from occurring in the absence of collagen.