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Mouse Anti-DDX39A Recombinant Antibody (2252C4a) (CBMAB-D0548-YC)

Provided herein is a Mouse monoclonal antibody, which binds to DExD-Box Helicase 39A (DDX39A). The antibody can be used for immunoassay techniques, such as Dot, FC, ICC, IF, IP, WB.
See all DDX39A antibodies
Published Data
Fig.1 Hematoxylin-eosin staining (A–C) and immunohistochemical staining (D–F) for DDX39 of normal urothelium and bladder cancers. (A,D) Normal bladder urothelium; (B,E) DDX39high (positive cells 50%) pTa cancer; (C,F) DDX39low (positive cells <50%) pT2 c
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Fig.2 Two siRNAs for DDX39 (si-DDX39 A and si-DDX39 B) downregulated the protein (A) and mRNA expression of DDX39 (B). **P < 0.01.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
2252C4a
Antibody Isotype
IgG1
Application
Dot, FC, ICC, IF, IP, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DExD-Box Helicase 39A
Introduction
DDX39A belongs to the DEAD box protein family. These proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is thought to play a role in the prognosis of patients with gastrointestinal stromal tumors.
Entrez Gene ID
10212
UniProt ID
O00148
Alternative Names
DExD-Box Helicase 39A; DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 39; UAP56-Related Helicase, 49 KDa; Nuclear RNA Helicase URH49; DEAD-Box Helicase 39A; DEAD Box Protein 39; DDX39; Nuclear RNA Helicase, DECD Variant Of DEAD Box Family; DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 39A;
Function
Isoform 1:
Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus.
Biological Process
mRNA 3'-end processing Source: Reactome
mRNA export from nucleus Source: UniProtKB
mRNA splicing, via spliceosome Source: UniProtKB
RNA export from nucleus Source: Reactome
Cellular Location
Nucleus; Cytoplasm. Can translocate to the cytoplasm in the presence of MX1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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