Mouse Anti-DDX39A Recombinant Antibody (2252C4a) (CBMAB-D0548-YC)

Name: Mouse Anti-DDX39A Recombinant Antibody (2252C4a)
SKU: CBMAB-D0548-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2252C4a

Application

Dot, FC, ICC, IF, IP, WB

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

DExD-Box Helicase 39A

Introduction

DDX39A belongs to the DEAD box protein family. These proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is thought to play a role in the prognosis of patients with gastrointestinal stromal tumors.

Entrez Gene ID

10212

UniProt ID

O00148

Alternative Names

DExD-Box Helicase 39A; DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 39; UAP56-Related Helicase, 49 KDa; Nuclear RNA Helicase URH49; DEAD-Box Helicase 39A; DEAD Box Protein 39; DDX39; Nuclear RNA Helicase, DECD Variant Of DEAD Box Family; DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 39A;

Function

Isoform 1:
Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus.

Biological Process

mRNA 3'-end processing Source: Reactome
mRNA export from nucleus Source: UniProtKB
mRNA splicing, via spliceosome Source: UniProtKB
RNA export from nucleus Source: Reactome

Cellular Location

Nucleus; Cytoplasm. Can translocate to the cytoplasm in the presence of MX1.

Saleem, I., Mirza, S., Sarkar, A., Raza, M., Mohapatra, B., Mushtaq, I., ... & Band, V. (2021). The mammalian ecdysoneless protein interacts with RNA helicase DDX39A to regulate nuclear mRNA export. Molecular and cellular biology, 41(7), e00103-21.

Shi, P., Guo, Y., Su, Y., Zhu, M., Fu, Y., Chi, H., ... & Huang, J. (2020). SUMOylation of DDX39A alters binding and export of antiviral transcripts to control innate immunity. The Journal of Immunology, 205(1), 168-180.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Rabbit Anti-DDX39A Recombinant Antibody (D0548) (CAT#: V2LY-0425-LY46)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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