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Mouse Anti-DDX56 Recombinant Antibody (2E5) (CBMAB-D0597-YC)

Provided herein is a Mouse monoclonal antibody, which binds to DEAD-Box Helicase 56 (DDX56). The antibody can be used for immunoassay techniques, such as WB, IHC-P.
See all DDX56 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2E5
Antibody Isotype
IgG1
Application
WB, IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DEAD (Asp-Glu-Ala-Asp) box polypeptide 56
Introduction
DDX56 belongs to the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene shows ATPase activity in the presence of polynucleotides and associates with nucleoplasmic 65S preribosomal particles. This gene may be involved in ribosome synthesis, most likely during assembly of the large 60S ribosomal subunit.
Entrez Gene ID
54606
UniProt ID
Q9NY93
Alternative Names
DEAD-Box Helicase 56; ATP-Dependent 61 KDa Nucleolar RNA Helicase; DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 56; DEAD (Asp-Glu-Ala-Asp) Box Helicase 56; Nucleolar Helicase Of 61 KDa; DEAD Box Protein 21; DEAD Box Protein 56; DDX21; NOH61;
Function
May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity.
Biological Process
Positive regulation of neuron projection development Source: Ensembl
rRNA processing Source: UniProtKB-KW
Cellular Location
Nucleolus

Pryszlak, M., Wiggans, M., Chen, X., Jaramillo, J. E., Burns, S. E., Richards, L. M., ... & Pearson, B. J. (2021). The DEAD-box helicase DDX56 is a conserved stemness regulator in normal and cancer stem cells. Cell Reports, 34(13), 108903.

Wu, Q., Luo, X., Terp, M. G., Li, Q., Li, Y., Shen, L., ... & Ditzel, H. J. (2021). DDX56 modulates post-transcriptional Wnt signaling through miRNAs and is associated with early recurrence in squamous cell lung carcinoma. Molecular cancer, 20(1), 1-17.

Zhang, L., & Li, X. (2021). DEAD-Box RNA Helicases in Cell Cycle Control and Clinical Therapy. Cells, 10(6), 1540.

Zhu, C., Zhang, X., Kourkoumelis, N., Shen, Y., & Huang, W. (2020). Integrated analysis of DEAD-Box Helicase 56: a potential oncogene in osteosarcoma. Frontiers in bioengineering and biotechnology, 588.

Li, D., Fu, S., Wu, Z., Yang, W., Ru, Y., Shu, H., ... & Zheng, H. (2020). DDX56 inhibits type I interferon by disrupting assembly of IRF3–IPO5 to inhibit IRF3 nucleus import. Journal of cell science, 133(5), jcs230409.

Taschuk, F., Tapescu, I., Moy, R. H., & Cherry, S. (2020). DDX56 Binds to Chikungunya Virus RNA To Control Infection. Mbio, 11(5), e02623-20.

Kouyama, Y., Masuda, T., Fujii, A., Ogawa, Y., Sato, K., Tobo, T., ... & Mimori, K. (2019). Oncogenic splicing abnormalities induced by DEAD‐Box Helicase 56 amplification in colorectal cancer. Cancer science, 110(10), 3132-3144.

Fu, S., Li, L., Zhang, J., Li, D., & Zheng, H. (2019). Porcine DDX56 regulates the foot and mouth disease virus replication and the virus-triggered RLR pathway. Acta Veterinaria et Zootechnica Sinica, 50(9), 1849-1856.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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