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Mouse Anti-DDX56 Recombinant Antibody (2E5) (V2LY-0425-LY97)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
2E5
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 323-547 of human DDX56 produced in E.coli.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:2,000
IHC1:150

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
BSA & Glycerol & PBS
Preservative
Sodium Azide
Concentration
1 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
DEAD (Asp-Glu-Ala-Asp) box polypeptide 56
Entrez Gene ID
54606
UniProt ID
Q9NY93
Function
May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity.
Biological Process
Positive regulation of neuron projection development Source: Ensembl
rRNA processing Source: UniProtKB-KW
Cellular Location
Nucleolus
More Infomation

Pryszlak, M., Wiggans, M., Chen, X., Jaramillo, J. E., Burns, S. E., Richards, L. M., ... & Pearson, B. J. (2021). The DEAD-box helicase DDX56 is a conserved stemness regulator in normal and cancer stem cells. Cell Reports, 34(13), 108903.

Wu, Q., Luo, X., Terp, M. G., Li, Q., Li, Y., Shen, L., ... & Ditzel, H. J. (2021). DDX56 modulates post-transcriptional Wnt signaling through miRNAs and is associated with early recurrence in squamous cell lung carcinoma. Molecular cancer, 20(1), 1-17.

Zhang, L., & Li, X. (2021). DEAD-Box RNA Helicases in Cell Cycle Control and Clinical Therapy. Cells, 10(6), 1540.

Zhu, C., Zhang, X., Kourkoumelis, N., Shen, Y., & Huang, W. (2020). Integrated analysis of DEAD-Box Helicase 56: a potential oncogene in osteosarcoma. Frontiers in bioengineering and biotechnology, 588.

Li, D., Fu, S., Wu, Z., Yang, W., Ru, Y., Shu, H., ... & Zheng, H. (2020). DDX56 inhibits type I interferon by disrupting assembly of IRF3–IPO5 to inhibit IRF3 nucleus import. Journal of cell science, 133(5), jcs230409.

Taschuk, F., Tapescu, I., Moy, R. H., & Cherry, S. (2020). DDX56 Binds to Chikungunya Virus RNA To Control Infection. Mbio, 11(5), e02623-20.

Kouyama, Y., Masuda, T., Fujii, A., Ogawa, Y., Sato, K., Tobo, T., ... & Mimori, K. (2019). Oncogenic splicing abnormalities induced by DEAD‐Box Helicase 56 amplification in colorectal cancer. Cancer science, 110(10), 3132-3144.

Fu, S., Li, L., Zhang, J., Li, D., & Zheng, H. (2019). Porcine DDX56 regulates the foot and mouth disease virus replication and the virus-triggered RLR pathway. Acta Veterinaria et Zootechnica Sinica, 50(9), 1849-1856.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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